The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

The vertebrate vasculature displays high organotypic specialization, with the structure and
function of blood vessels catering to the specific needs of each tissue. A unique feature of …

INTRODUCTION Vision provides a critical survival advantage but requires a tight coupling
between neuronal energy demands and their vascular supply. The degeneration and …

Background: Angiogenesis is a dynamic process that involves expansion of a preexisting
vascular network that can occur in a number of physiological and pathological settings …

Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

The retinal capillary vasculature serves the formidable role of supplying the metabolically
active inner and middle retina. In the parafoveal region, the retinal capillary plexuses (RCP) …

Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …

Attenuating pathological angiogenesis in diseases characterized by neovascularization
such as diabetic retinopathy has transformed standards of care. Yet little is known about the …

Vascular dysfunction is a hallmark of ischemic, cancer, and inflammatory diseases,
contributing to disease progression. Circular RNAs (circRNAs) are endogenous non-coding …

Endothelial cell (EC) metabolism is emerging as a regulator of angiogenesis, but the precise
role of glutamine metabolism in EC s is unknown. Here, we show that depriving EC s of …