Although previously restricted to a limited number of medical conditions, there is a growing
appreciation that 'autoimmune'(or immune-mediated) processes are important aspects of a …

Pyroptosis is a form of programmed cell death associated with activation of inflammasomes
and inflammatory caspases, proteolytic cleavage of gasdermin proteins (forming pores in the …

Extracellular microparticles provide a means of cell-to-cell communication and can promote
information exchanges between adjacent or distant cells. Platelets are cell fragments that …

Transcription factors bind promoter or regulatory sequences of a gene to regulate its rate of
transcription. However, they are also detected in anucleated platelets. The transcription …

Erectile dysfunction (ED) is a prevalent disease that causes sexual dysfunction in males.
Inflammation‑induced endothelial dysfunction is a fundamental pathophysiological symptom …

Platelets are the anucleate cells that impact the immune system by releasing their cellular
contents (1). Immunological reactions are responsible for effectively clearing foreign …

Background Alterations of the trimethylation of histone 3 lysine 4 (H3K4me3) mark in
monocytes are implicated in the development of autoimmune diseases. Therefore, the …

Antiphospholipid antibody syndrome (APS) is an autoimmune disorder characterised by
thrombosis and the presence of antiphospholipid antibodies (aPL): lupus anticoagulant …

Splenectomised β‐thalassaemia/haemoglobin E (HbE) patients have increased levels of
circulating microparticles or medium extra‐cellular vesicles (mEVs). The splenectomised …

In the 1980s, researchers already understood the correlation between bacterial DNA and
immune activation in vitro (1), ie, they knew that exposing macrophages to bacterial DNA …