Neuromyelitis optica spectrum disorders (NMOSD) are autoantibody mediated chronic
inflammatory diseases. Serum antibodies (Abs) against the aquaporin-4 water channel lead …

Acute optic neuritis is the most common optic neuropathy affecting young adults. Exciting
developments have occurred over the past decade in understanding of optic neuritis …

Background No approved therapies exist for neuromyelitis optica spectrum disorder
(NMOSD), a rare, relapsing, autoimmune, inflammatory disease of the CNS that causes …

Purpose To characterize the clinical phenotype of myelin oligodendrocyte glycoprotein
antibody (MOG-IgG) optic neuritis. Design Observational case series. Methods Setting …

Neuromyelitis optica (NMO, Devic's syndrome), long considered a clinical variant of multiple
sclerosis, is now regarded as a distinct disease entity. Major progress has been made in the …

Background The diagnostic and pathophysiological relevance of antibodies to aquaporin-4
(AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been …

Summary The term 'neuromyelitis optica'('Devic's syndrome', NMO) refers to a syndrome
characterized by optic neuritis and myelitis. In recent years, the condition has raised …

Background Serum autoantibodies against the water channel aquaporin-4 (AQP4) are
important diagnostic biomarkers and pathogenic factors for neuromyelitis optica (NMO) …

Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple
sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of …

The discovery of a novel serum autoantibody (termed NMO-IgG or AQP4-Ab) in a subset of
patients in 2004 has revived interest in neuromyelitis optica (NMO). While the history of …