Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC1 and BORC complexes

C Hartwig, WJ Monis, X Chen… - Developmental …, 2018 - Wiley Online Library
The biogenesis of lysosomerelated organelles complex1 (BLOC1) and the blocone
related complex (BORC) are the cytosolic protein complexes required for specialized …

AS3MT Polymorphism: A Risk Factor for Epilepsy Susceptibility and Adverse Drug Reactions to Valproic Acid and Oxcarbazepine Treatment in Children From South …

X Fan, Y Chen, J Lu, W Li, X Li, H Guo… - Frontiers in …, 2021 - frontiersin.org
Epilepsy is a common neurologic disorder characterized by intractable seizures, involving
genetic factors. There is a need to develop reliable genetic markers to predict the risk of …

Genetic Determinants of Reduced Arsenic Metabolism Efficiency in the 10q24.32 Region Are Associated With Reduced AS3MT Expression in Multiple Human Tissue …

M Chernoff, L Tong, K Demanelis… - Toxicological …, 2020 - academic.oup.com
Approximately 140 million people worldwide are exposed to inorganic arsenic through
contaminated drinking water. Chronic exposure increases risk for cancers as well as …

Cortical cellular diversity and development in schizophrenia

AJ Price, AE Jaffe, DR Weinberger - Molecular psychiatry, 2021 - nature.com
While a definitive understanding of schizophrenia etiology is far from current reality, an
increasing body of evidence implicates perturbations in early development that alter the …

Neuroepigenetics of schizophrenia

G Punzi, R Bharadwaj, G Ursini - Progress in Molecular Biology and …, 2018 - Elsevier
Schizophrenia is a complex disorder of the brain, where genetic variants explain only a
portion of risk. Neuroepigenetic mechanisms may explain the remaining share of risk, as …

Variability of 128 schizophrenia-associated gene variants across distinct ethnic populations

K Ohi, T Shimada, T Yasuyama, T Uehara… - Translational …, 2017 - nature.com
Schizophrenia is a common polygenetic disease affecting 0.5–1% of individuals across
distinct ethnic populations. PGC-II, the largest genome-wide association study investigating …

[HTML][HTML] The cliff edge model of the evolution of schizophrenia: mathematical, epidemiological, and genetic evidence

P Mitteroecker, GP Merola - Neuroscience & Biobehavioral Reviews, 2024 - Elsevier
How has schizophrenia, a condition that significantly reduces an individual's evolutionary
fitness, remained common across generations and cultures? Numerous theories about the …

[图书][B] The brain in context: A pragmatic guide to neuroscience

JD Moreno, J Schulkin - 2020 - degruyter.com
REFERENCES Page 1 Abe, N. (2011). “How the Brain Shapes Deception: An Integrated
Review of the Literature.” Neuroscientist 17 (5): 560– 574. Abe, N., and JD Greene. (2014). “Response …

Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function

ZH Yang, X Cai, ZL Ding, W Li, CY Zhang, JH Huo… - BMC medicine, 2023 - Springer
Background Schizophrenia and bipolar disorder (BD) are believed to share clinical
symptoms, genetic risk, etiological factors, and pathogenic mechanisms. We previously …

Analysis of transcript levels of a few schizophrenia candidate genes in neurons from a transgenic mouse embryonic stem cell model overexpressing DNMT1

S Saxena, PA Maroju, S Choudhury, A Anne… - Gene, 2020 - Elsevier
Abstract Overexpression of DNA Methyltransferase I (DNMT1) is considered as one of the
etiological factors for schizophrenia (SZ). However, information on genes subjected to …