Background Brain arterial diameters (BADs) are novel imaging biomarkers of
cerebrovascular disease, cognitive decline, and dementia. Traditional vascular risk factors …

BackgroundThe Arsenic (+ 3 oxidation state) methyltransferase (AS3MT) gene has been
identified as a top risk gene for schizophrenia in several large-scale genome-wide …

Inorganic arsenic is highly toxic and carcinogenic to humans. Exposed individuals vary in
their ability to metabolize arsenic, and variability in arsenic metabolism efficiency (AME) is …

Psychotic symptoms are a common and debilitating feature of Alzheimer's disease (AD) and
are associated with a more rapid course of decline. Current evidence from postmortem and …

Highlights•The genetic bases of Parkinson's disease (PD) are largely unknown.•Recent
studies have identified a large number of putative genetic risk factors for PD.•Patient-specific …

Multiple types of variations have been postulated to confer risk of schizophrenia and bipolar
disorder, but majority of present GWAS solely focused on SNPs or small indels, and the …

Background Previous findings suggest that differences in brain expression of a human-
specific long intergenic noncoding RNA (LINC01268; GRCh37/hg19: LOC285758) may be …

RNA splicing is a key mechanism linking genetic variation and complex diseases, including
schizophrenia. Splicing profiles are particularly diverse in the brain, but it is difficult to …

Accumulating studies have been conducted to identify risk genes and relevant biological
mechanisms underlying major depressive disorder (MDD). In particular, transcriptomic …

Mental illness is increasingly recognized as both a significant cost to society and a
significant area of opportunity for biological breakthrough. As-omics and imaging …