G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a
critical role in nervous system function by transmitting signals between cells and their …

Fluorine is an element renowned for its unique properties. Its powerful capability to modulate
molecular properties makes it an attractive substituent for protein binding ligands; however …

Abstract Proton-sensing G Protein Coupled Receptors (GPCRs) sense changes in the
extracellular pH to effect cell signaling for cellular homeostasis. They tend to be …

Abstract Changes in structure and dynamics elicited by agonist ligand binding at the
extracellular side of G protein coupled receptors (GPCRs) must be relayed to the …

There are> 800 human G protein-coupled receptors (GPCRs). Around half (400) have
sensory functions mediating olfaction, taste, light perception, and pheromone signalling. The …

Alzheimer's disease (AD) is caused by plaque agglomeration and entanglement in several
areas of the neural cells, which leads to apoptosis. The main etiology of AD is senile …

G-protein-coupled receptors (GPCRs) are integral membrane proteins that transduce
chemical signals from the extracellular matrix into the cell. Traditional drug design has …

This paper is the forty-sixth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …