Ischemia-reperfusion injury is an important cause of liver damage occurring during surgical
procedures including hepatic resection and liver transplantation, and represents the main …

The development of cholangiopathies after liver transplantation impacts on the quality and
duration of graft and patient survival, contributing to higher costs as numerous interventions …

Objective: The aim of this study was to evaluate peak serum alanine aminotransferase (ALT)
and postoperative clinical outcomes after hypothermic oxygenated machine perfusion …

Background & Aims Machine perfusion is a novel method intended to optimize livers before
transplantation. However, its effect on morbidity within a 1-year period after transplantation …

Background Mitochondrial succinate accumulation has been suggested as key event for
ischemia reperfusion injury in mice. No specific data are however available on behavior of …

Normothermic ex situ liver perfusion might allow viability assessment of livers before
transplantation. Perfusion characteristics were studied in 47 liver perfusions, of which 22 …

Background & Aims Donation after circulatory death (DCD) liver transplantation is known for
potentially worse outcomes because of higher rates of graft non-function or irreversible …

Objective: The aim of this study was to determine the predictive value of machine perfusate
analysis on graft outcome. Background: Ex situ machine perfusion (MP) is gaining …

Hypothermic Oxygenated Perfusion (HOPE) of the liver can reduce the incidence of early
allograft dysfunction (EAD) and failure in extended criteria donors (ECD) grafts, although …

Background: Exposure of donor liver grafts to prolonged periods of warm ischemia before
procurement causes injuries including intrahepatic cholangiopathy, which may lead to graft …