Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity

G Jia, MA Hill, JR Sowers - Circulation research, 2018 - Am Heart Assoc
Heart failure and related morbidity and mortality are increasing at an alarming rate, in large
part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes …

An overview of heart rate variability metrics and norms

F Shaffer, JP Ginsberg - Frontiers in public health, 2017 - frontiersin.org
Healthy biological systems exhibit complex patterns of variability that can be described by
mathematical chaos. Heart rate variability (HRV) consists of changes in the time intervals …

Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy

G Jia, VG DeMarco, JR Sowers - Nature Reviews Endocrinology, 2016 - nature.com
Insulin resistance, type 2 diabetes mellitus and associated hyperinsulinaemia can promote
the development of a specific form of cardiomyopathy that is independent of coronary artery …

Breath of life: the respiratory vagal stimulation model of contemplative activity

RJS Gerritsen, GPH Band - Frontiers in human neuroscience, 2018 - frontiersin.org
Contemplative practices, such as meditation and yoga, are increasingly popular among the
general public and as topics of research. Beneficial effects associated with these practices …

A healthy heart is not a metronome: an integrative review of the heart's anatomy and heart rate variability

F Shaffer, R McCraty, CL Zerr - Frontiers in psychology, 2014 - frontiersin.org
Heart rate variability (HRV), the change in the time intervals between adjacent heartbeats, is
an emergent property of interdependent regulatory systems that operate on different time …

Current directions in the auricular vagus nerve stimulation I–a physiological perspective

E Kaniusas, S Kampusch, M Tittgemeyer… - Frontiers in …, 2019 - frontiersin.org
Electrical stimulation of the auricular vagus nerve (aVNS) is an emerging technology in the
field of bioelectronic medicine with applications in therapy. Modulation of the afferent vagus …

Implications of underlying mechanisms for the recognition and management of diabetic cardiomyopathy

TH Marwick, R Ritchie, JE Shaw, D Kaye - Journal of the American College …, 2018 - jacc.org
Heart failure is a complex clinical syndrome, the incidence and prevalence of which is
increased in diabetes mellitus, pre-diabetes, and obesity. Although this may arise from …

Heart rate variability biofeedback: how and why does it work?

PM Lehrer, R Gevirtz - Frontiers in psychology, 2014 - frontiersin.org
In recent years there has been substantial support for heart rate variability biofeedback
(HRVB) as a treatment for a variety of disorders and for performance enhancement. Since …

Adrenergic nervous system in heart failure: pathophysiology and therapy

A Lymperopoulos, G Rengo, WJ Koch - Circulation research, 2013 - Am Heart Assoc
Heart failure (HF), the leading cause of death in the western world, develops when a cardiac
injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It …

Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment

BA Borlaug, WJ Paulus - European heart journal, 2011 - academic.oup.com
Half of patients with heart failure (HF) have a preserved left ventricular ejection fraction
(HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF …