The current focus of medicine on molecular genetics ignores the physical basis of disease
even though many of the problems that lead to pain and morbidity, and bring patients to the …

The major challenge in biology today is biocomplexity: the need to explain how cell and
tissue behaviors emerge from collective interactions within complex molecular networks …

Examines the role of anoikis in cell death. Identification of broad range of cellular responses
to loss of adhesion that utilize diverse signaling and apoptotic pathways; Link of the …

Hypertrophic scars occur following cutaneous wounding and result in severe functional and
esthetic defects. The pathophysiology of this process remains unknown. Here, we …

▪ Abstract Mechanical forces play an important role in the organization, growth, maturation,
and function of living tissues. At the cellular level, many of the biological responses to …

Great advances have been made in the identification of the soluble angiogenic factors,
insoluble extracellular matrix (ECM) molecules, and receptor signaling pathways that …

Programmed cell death is crucial for the development and maintenance of multicellular
organisms. The decision to live, or to die, depends, at the cellular level, upon the cell's …

It has long been thought that the effectiveness and efficiency of physical therapy would
improve if our understanding of the cell biology/biochemistry that participates in mechanics …

Although standard anticancer chemotherapeutic drugs have been designed to inhibit the
survival or growth of rapidly dividing tumor cells, it is possible to enhance the efficacy of such …

▪ Abstract Cells adhere to the extracellular matrix throughout most of their lifetime. This close,
intimate contact with the matrix exerts an extraordinary control on the behavior of cells …