Topical and transdermal drug delivery are advantageous administration routes, especially
when treating diseases and conditions with a skin etiology. Nevertheless, conventional …

Transient receptor potential vanilloid 1 (TRPV1) is a transmembrane and non-selective
cation channel protein, which can be activated by various physical and chemical stimuli …

Alzheimer's disease (AD) is a progressive degenerative neurological condition
characterized by cognitive decline, primarily affecting memory and logical thinking, attributed …

Background: Mechanisms for how environmental chemicals might influence pain has
received little attention. Epidemiological studies suggest that environmental factors such as …

Advancements in computational techniques have transformed glaucoma research, providing
a deeper understanding of genetics, disease mechanisms, and potential therapeutic targets …

Background: Chemotherapy-induced neuropathic pain (CINP) is a debilitating side effect in
individuals undergoing cancer treatment. Treatment of CINP with the current available …

The present research investigates the amount of capsaicin and dihydrocapsaicin in three
parts of chili extracts (pericarp, seeds, and placenta). Moreover, inhibition potential of …

Identification of transient receptor potential cation channel, subfamily V member 1 (TRPV1),
also known as capsaicin receptor, in 1997 was a milestone achievement in the research on …

The spicy properties of foods are contributed by various spicy flavor substances (SFs) such
as capsaicin, piperine, and allicin. Beyond their distinctive sensory characteristics, SFs also …

We aimed to investigate the role of capsaicin (CAP) in modulating lipopolysaccharide (LPS)-
induced hepatic and intestinal inflammation, oxidative stress, and its colonic microflora in …