Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary
megakaryocytes. Activated platelets adhere to the damaged endothelium by means of …

The negatively charged aminophospholipid, phosphatidylserine (PtdSer), is located in the
inner leaflet of the plasma membrane in normal cells, and may be exposed to the outer …

Background: Chronic kidney disease (CKD) is a global public health problem with a high
mortality rate and a rapid progression to end-stage kidney disease (ESKD). Recently, the …

Blood platelets play a central hemostatic role,(i) as they repair vascular epithelial damage,
and (ii) they play immune defense roles, as they have the capacity to produce and secrete …

In the light of growing global epidemic of type 2 diabetes mellitus (T2DM), significant efforts
are made to discover next-generation biomarkers for early detection of the disease. Multiple …

Platelets play well-recognized roles in inflammation, but their cell of origin—the
megakaryocyte—is not typically considered an immune lineage. Megakaryocytes are large …

Background Traumatic injury can lead to dysregulation of the normal clotting system,
resulting in hemorrhagic and thrombotic complications. Platelet activation is robust following …

Background Platelet-rich plasma (PRP) improves the healing of refractory wounds, and its
application is receiving more attention in the field of wound repair. However, when a …

Platelets are anucleated cells derived from megakaryocytes that are primarily responsible
for hemostasis. However, in recent years, these cytoplasts have become increasingly …

Despite their humble origins as anuclear fragments of megakaryocytes, platelets have
emerged as versatile mediators of thrombosis and immunity. The diverse spectrum of …