A widely held dogma in the preclinical addiction field is that females are more vulnerable
than males to drug craving and relapse. Here, we first review clinical studies on sex …

It was suggested in 1986 that cue-induced cocaine craving increases progressively during
early abstinence and remains high during extended periods of time. Clinical evidence now …

Background There are sex differences in addiction behaviors. To develop a pre-clinical
animal model to investigate this, the present study examined sex differences in sucrose …

Studies using rodent models have shown that relapse to drug or food seeking increases
progressively during abstinence, a behavioral phenomenon termed “incubation of craving.” …

Persistent susceptibility to cue-induced relapse is a cardinal feature of addiction.
Discriminative stimuli (DSs) are one type of drug-associated cue that signal drug availability …

Relapse is a major problem in treating methamphetamine use disorder.“Incubation of
craving” during abstinence is a rat model for persistence of vulnerability to craving and …

Patients with opioid use disorder experience high rates of relapse during recovery, despite
successful completion of rehabilitation programs. A key factor contributing to this problem is …

Relapse to drug use during abstinence is a defining feature of addiction. To date, however,
results from studies using rat relapse/reinstatement models have yet to result in FDA …

Incubation of craving refers to the intensification of drug-seeking behavior in response to
reward-paired cues over the course of abstinence. In rodents, craving and drug-seeking …

Drug addiction is a chronic relapsing disorder of compulsive drug use. Studies of the
neurobehavioral factors that promote drug relapse have yet to produce an effective …