T cell receptor (TCR) signaling in health and disease
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
Cutaneous T cell lymphoma
R Dummer, MH Vermeer, JJ Scarisbrick… - Nature Reviews …, 2021 - nature.com
Primary cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphomas
that present in the skin with no evidence of extracutaneous disease at the time of diagnosis …
that present in the skin with no evidence of extracutaneous disease at the time of diagnosis …
Cobomarsen, an oligonucleotide inhibitor of miR‐155, co‐ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T …
AG Seto, X Beatty, JM Lynch… - British journal of …, 2018 - Wiley Online Library
Summary miR‐155, a microRNA associated with poor prognosis in lymphoma and
leukaemia, has been implicated in the progression of mycosis fungoides (MF), the most …
leukaemia, has been implicated in the progression of mycosis fungoides (MF), the most …
PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis
T Wartewig, Z Kurgyis, S Keppler, K Pechloff… - Nature, 2017 - nature.com
T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive
malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells …
malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells …
Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas
D Vallois, MPD Dobay, RD Morin… - Blood, The Journal …, 2016 - ashpublications.org
Angioimmunoblastic T-cell lymphoma (AITL) and other lymphomas derived from follicular T-
helper cells (TFH) represent a large proportion of peripheral T-cell lymphomas (PTCLs) with …
helper cells (TFH) represent a large proportion of peripheral T-cell lymphomas (PTCLs) with …
Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin
Tumours most often arise from progression of precursor clones within a single anatomical
niche. In the bone marrow, clonal progenitors can undergo malignant transformation to …
niche. In the bone marrow, clonal progenitors can undergo malignant transformation to …
[HTML][HTML] Pembrolizumab in relapsed and refractory mycosis fungoides and Sézary syndrome: a multicenter phase II study
MS Khodadoust, AH Rook, P Porcu, F Foss… - Journal of Clinical …, 2020 - ncbi.nlm.nih.gov
Pembrolizumab in Relapsed and Refractory Mycosis Fungoides and Sézary Syndrome: A
Multicenter Phase II Study - PMC Back to Top Skip to main content NIH NLM Logo Access keys …
Multicenter Phase II Study - PMC Back to Top Skip to main content NIH NLM Logo Access keys …
Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma
Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin
lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of …
lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of …
[PDF][PDF] Genomic profiling of childhood tumor patient-derived xenograft models to enable rational clinical trial design
Accelerating cures for children with cancer remains an immediate challenge as a result of
extensive oncogenic heterogeneity between and within histologies, distinct molecular …
extensive oncogenic heterogeneity between and within histologies, distinct molecular …
Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity
Cutaneous T-cell lymphomas (CTCLs) are a clinically heterogeneous collection of
lymphomas of the skin-homing T cell. To identify molecular drivers of disease phenotypes …
lymphomas of the skin-homing T cell. To identify molecular drivers of disease phenotypes …