Administration of cisplatin, a common chemotherapeutic drug, has an inevitable side effect
of sensorineural hearing loss. The main etiologies are stria vascularis injury, spiral ganglion …

Sensorineural deafness becomes an inevitable worldwide healthy problem, yet the current
curative therapy is limited. Emerging evidences demonstrate mitochondrial dysfunction …

Cisplatin is a commonly used chemotherapeutic agent with proven efficacy in treating
various malignancies, including testicular, ovarian, cervical, breast, bladder, head and neck …

Background: Cisplatin (Cp) is an antineoplastic agent with a dose-limiting nephrotoxicity. Cp-
induced nephrotoxicity is characterized by the interplay of oxidative stress, inflammation …

Significance: The stria vascularis, located in the inner ear, consists of three layers, one of
which is the blood–labyrinth barrier (BLB). It is formed by endothelial cells, sealed together …

Sensorineural hearing loss is the most common type of hearing loss in adults and occurs
due to damage of the inner ear caused by a range of factors including ageing, excessive …

Cisplatin is a first-line chemotherapy drug for lung adenocarcinoma (LUAD). However, its
therapeutic efficacy is limited because of serious side effects and acquired drug resistance …

Objective To investigate the effect and mechanism of Pou4f3 gene mutation on pyroptosis in
cochleae of cisplatin-induced deafness mice. Methods: Mice were intraperitoneally injected …

Background: Cisplatin is a widely used anticancer drug in clinic, but it has a damaging effect
on skeletal muscle cells. Clinical observation showed that Yiqi Chutan formula (YCF) had a …

The blood-labyrinth-barrier (BLB) is a semipermeable boundary between the vasculature
and three separate fluid spaces of the inner ear, the perilymph, the endolymph and the …