[HTML][HTML] Cisplatin-induced ototoxicity: From signaling network to therapeutic targets
X Wang, Y Zhou, D Wang, Y Wang, Z Zhou… - Biomedicine & …, 2023 - Elsevier
Administration of cisplatin, a common chemotherapeutic drug, has an inevitable side effect
of sensorineural hearing loss. The main etiologies are stria vascularis injury, spiral ganglion …
of sensorineural hearing loss. The main etiologies are stria vascularis injury, spiral ganglion …
[HTML][HTML] Mitochondrial dysfunction in hearing loss: Oxidative stress, autophagy and NLRP3 inflammasome
P Li, S Li, L Wang, H Li, Y Wang, H Liu… - Frontiers in Cell and …, 2023 - frontiersin.org
Sensorineural deafness becomes an inevitable worldwide healthy problem, yet the current
curative therapy is limited. Emerging evidences demonstrate mitochondrial dysfunction …
curative therapy is limited. Emerging evidences demonstrate mitochondrial dysfunction …
[HTML][HTML] Molecular characteristics of cisplatin-induced ototoxicity and therapeutic interventions
WJT Tan, SM Vlajkovic - International Journal of Molecular Sciences, 2023 - mdpi.com
Cisplatin is a commonly used chemotherapeutic agent with proven efficacy in treating
various malignancies, including testicular, ovarian, cervical, breast, bladder, head and neck …
various malignancies, including testicular, ovarian, cervical, breast, bladder, head and neck …
[HTML][HTML] TLR4/inflammasomes cross-talk and pyroptosis contribute to N-Acetyl cysteine and chlorogenic acid protection against cisplatin-induced nephrotoxicity
Background: Cisplatin (Cp) is an antineoplastic agent with a dose-limiting nephrotoxicity. Cp-
induced nephrotoxicity is characterized by the interplay of oxidative stress, inflammation …
induced nephrotoxicity is characterized by the interplay of oxidative stress, inflammation …
Blood–Labyrinth Barrier in Health and Diseases: Effect of Hormetic Nutrients
A Cosentino, A Agafonova, S Modafferi… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: The stria vascularis, located in the inner ear, consists of three layers, one of
which is the blood–labyrinth barrier (BLB). It is formed by endothelial cells, sealed together …
which is the blood–labyrinth barrier (BLB). It is formed by endothelial cells, sealed together …
[HTML][HTML] The NLRP3 inflammasome as a target for sensorineural hearing loss
GE Gregory, KJ Munro, KN Couper… - Clinical …, 2023 - Elsevier
Sensorineural hearing loss is the most common type of hearing loss in adults and occurs
due to damage of the inner ear caused by a range of factors including ageing, excessive …
due to damage of the inner ear caused by a range of factors including ageing, excessive …
[HTML][HTML] Inetetamab, a novel anti-HER2 monoclonal antibody, exhibits potent synergistic anticancer effects with cisplatin by inducing pyroptosis in lung …
J Cui, Y He, F Zhu, W Gong, R Zuo… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Cisplatin is a first-line chemotherapy drug for lung adenocarcinoma (LUAD). However, its
therapeutic efficacy is limited because of serious side effects and acquired drug resistance …
therapeutic efficacy is limited because of serious side effects and acquired drug resistance …
Knockdown and mutation of Pou4f3 gene mutation promotes pyroptosis of cochleae in cisplatin-induced deafness mice by NLRP3/caspase-3/GSDME pathway
R Yu, K Wang, W Luo, H Jiang - Toxicology, 2022 - Elsevier
Objective To investigate the effect and mechanism of Pou4f3 gene mutation on pyroptosis in
cochleae of cisplatin-induced deafness mice. Methods: Mice were intraperitoneally injected …
cochleae of cisplatin-induced deafness mice. Methods: Mice were intraperitoneally injected …
Yiqi chutan formula reverses cisplatin-induced apoptosis and ferroptosis of skeletal muscle by alleviating oxidative stress
Y Wu, D Pi, S Zhou, W Wang, H Ye… - Integrative Cancer …, 2023 - journals.sagepub.com
Background: Cisplatin is a widely used anticancer drug in clinic, but it has a damaging effect
on skeletal muscle cells. Clinical observation showed that Yiqi Chutan formula (YCF) had a …
on skeletal muscle cells. Clinical observation showed that Yiqi Chutan formula (YCF) had a …
[HTML][HTML] A critical evaluation of “leakage” at the cochlear blood-stria-barrier and its functional significance
KK Ohlemiller, N Dwyer, V Henson… - Frontiers in Molecular …, 2024 - frontiersin.org
The blood-labyrinth-barrier (BLB) is a semipermeable boundary between the vasculature
and three separate fluid spaces of the inner ear, the perilymph, the endolymph and the …
and three separate fluid spaces of the inner ear, the perilymph, the endolymph and the …