Epilepsy is one of the most common and disabling neurologic conditions, yet we have an
incomplete understanding of the detailed pathophysiology and, thus, treatment rationale for …

We postulate that “system epilepsies”(SystE) are due to an enduring propensity to generate
seizures of functionally characterized brain systems. Data supporting this hypothesis—that …

Epileptic encephalopathies represent a group of devastating epileptic disorders that occur
early in life and are often characterized by pharmaco-resistant epilepsy, persistent severe …

Objective To identify whether abnormal electroencephalography (EEG) connectivity is
present before the onset of epileptic spasms (ES) in infants with tuberous sclerosis complex …

The devastating developmental and epileptic encephalopathy of infantile epileptic spasms
syndrome (IESS) has numerous causes, including, but not limited to, brain injury, metabolic …

The application of metabolic imaging and genetic analysis, and now the development of
appropriate animal models, has generated critical insights into the pathogenesis of epileptic …

Infantile spasms (IS) are a catastrophic childhood epilepsy syndrome characterized by
flexion-extension spasms during infancy that progress to chronic seizures and cognitive …

Purpose: To evaluate initial magnetic resonance imaging (MRI) abnormalities in infantile
spasms, correlate them to clinical characteristics, and describe repeat imaging findings …

Background Infants suffer from a severe epileptic encephalopathy known as West syndrome
(WS). Treatment with adrenocorticotropic hormone (ACTH) indicates the involvement of the …

Abnormal high frequency oscillations (HFOs) in EEG recordings are thought to be reflections
of mechanisms responsible for focal seizure generation in the temporal lobe and neocortex …