Сalixresorcine cavitands bearing lipophilic cationic fragments in the construction of mitochondrial-targeting supramolecular nanoparticles

JE Morozova, CR Myaldzina, AD Voloshina… - Colloids and Surfaces A …, 2022 - Elsevier
The development of mitochondrial-targeting therapeutic nanoparticles is one of the crucial
tasks of nanotechnology and nanomedicine. Here the study of supramolecular macrocycles …

Roles of mitochondria in oral squamous cell carcinoma therapy: Friend or foe?

J Bai, L Wu, X Wang, Y Wang, Z Shang, E Jiang… - Cancers, 2022 - mdpi.com
Simple Summary Although many therapies have been applied in oral squamous cell
carcinoma, these therapies are still unsatisfactory. Recently, the mitochondrial role in oral …

Mitochondria-targeting polymer micelles in stepwise response releasing gemcitabine and destroying the mitochondria and nucleus for combined antitumor …

S Zhang, F Zheng, K Liu, S Liu, T Xiao, Y Zhu… - International Journal of …, 2022 - mdpi.com
Mitochondrial DNA and nuclear DNA are essential genetic material which play an important
role in maintaining normal metabolism, survival, and proliferation of cells. Constructing a …

Exploiting nuclear-mitochondrial cross-talk in theranostics: enhancing drug delivery and diagnostic precision

D Singh - Mitochondrion, 2024 - Elsevier
The dynamic interplay between nuclear and mitochondrial processes plays a pivotal role in
cellular homeostasis and disease progression. Exploiting this nuclear-mitochondrial cross …

Evaluation of Anticancer Activity of 1,3‐Oxazol‐4‐ylphosphonium Salts in Vitro

M Brusnakov, O Golovchenko, Y Velihina… - …, 2022 - Wiley Online Library
Abstract A novel series of 1, 3‐oxazol‐4‐yltriphenylphosphonium salts has been
synthesized and functionalized. Oxazole derivatives were subjected to NCI in vitro …

Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

SR Pandya, H Singh, MF Desimone, J Singh… - Materials …, 2024 - pubs.rsc.org
Cancer is a highly complex disease that affects lives and causes millions of deaths
worldwide. Several approaches are currently employed as cancer treatment options. Among …

TPP-based conjugates: potential targeting ligands

S Batheja, S Gupta, KK Tejavath, U Gupta - Drug Discovery Today, 2024 - Elsevier
Highlights•In this review, the pivotal role of triphenylphosphonium (TPP) and its conjugates
have been widely explored.•The mechanistic insights of TPP-based conjugates endowing …

Boron nanoparticles in chemotherapy and radiotherapy: the synthesis, state-of-the-art, and prospects

SA Uspenskii, PA Khaptakhanova - Russian Chemical Bulletin, 2022 - Springer
Boron neutron capture therapy (BNCT) is a radiotherapy method for cancer treatment based
on the nuclear reaction of the stable 10B isotope with epithermal neutrons that produces …

Novel triphenylphosphonium amphiphilic conjugates of glycerolipid type: Synthesis, cytotoxic and antibacterial activity, and targeted cancer cell delivery

OV Tsepaeva, AV Nemtarev, TN Pashirova… - RSC Medicinal …, 2023 - pubs.rsc.org
This work deals with the creation of new cationic triphenylphosphonium amphiphilic
conjugates of glycerolipid type (TPP-conjugates), bearing a pharmacophore terpenoid …

Aggregation-Induced Emission Luminogens for Enhanced Photodynamic Therapy: From Organelle Targeting to Tumor Targeting

J Zhou, F Qi, Y Chen, S Zhang, X Zheng, W He, Z Guo - Biosensors, 2022 - mdpi.com
Photodynamic therapy (PDT) has attracted much attention in the field of anticancer
treatment. However, PDT has to face challenges, such as aggregation caused by quenching …