Serotonin is a neurotransmitter involved in the modulation of a multitude of physiological
and behavioral processes. In spite of the relatively reduced number of serotonin-producing …

Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases,
including multiple sclerosis and experimental autoimmune encephalomyelitis,,,,,,–(EAE), an …

Astrocytes are heterogeneous glial cells of the central nervous system,–. However, the
physiological relevance of astrocyte diversity for neural circuits and behaviour remains …

Brain development requires appropriate regulation of serotonin (5-HT) signaling from
distinct tissue sources across embryogenesis. At the maternal-fetal interface, the placenta is …

The fetal brain of the mouse is thought to be dependent upon the placenta as a source of
serotonin (5-hydroxytryptamine; 5-HT) and other factors. How factors reach the developing …

The nervous and immune systems are highly developed, and each performs specialized
physiological functions. However, they work together, and their dysfunction is associated …

Objectives Osteoarthritis (OA) is a whole-joint disease in which the role of the infrapatellar fat
pad (IFP) in its pathogenesis is unclear. Our study explored the cellular heterogeneity of IFP …

Mood disorders are an enigmatic class of debilitating illnesses that affect millions of
individuals worldwide. While chronic stress clearly increases incidence levels of mood …

Astrocytes respond to all forms of central nervous system maladies. In a recent issue of
Nature, Lee et al. demonstrate that astrocytes encode inflammatory stimuli as epigenetic …

Background: Major depressive disorder (MDD), along with related mood disorders, is a
debilitating illness that affects millions of individuals worldwide. While chronic stress …