Abstract Prostaglandin E 2 (PGE 2) is one of the most typical lipid mediators produced from
arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on …

Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their
involvement in acquired and innate immunity. Increasing evidence now implicates mast cells …

The kynurenine pathway (KP) metabolizes the essential amino acid tryptophan and
generates a number of neuroactive metabolites collectively called the kynurenines …

This protocol details a method to actively induce experimental allergic encephalomyelitis
(EAE), a widely used animal model for studies of multiple sclerosis. EAE is induced by …

Multiple Sclerosis (MS) is a complex disease with an unknown etiology and no effective
cure, despite decades of extensive research that led to the development of several partially …

Multiple sclerosis (MS) is a spontaneous, acquired, inflammatory demyelinating disease of
the human CNS. Because it involves a complex interaction between two of the most intricate …

Mast cells are well known for their involvement in allergic and anaphylactic reactions, during
which immunoglobulin E (IgE) receptor (FcɛRI) aggregation leads to exocytosis of the …

M. Müller, S. Carter, MJ Hofer and IL Campbell (2010) Neuropathology and Applied
Neurobiology36, 368–387 The chemokine receptor CXCR3 and its ligands CXCL9 …

Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with
particularly high evolutionary conservation of ligand binding domain. The receptor exists in …

Multiple sclerosis (MS) is considered a prototypic autoimmune disease of the central
nervous system (CNS). A complex genetic background with the HLA-DR15 haplotype as the …