Challenging the utility of polygenic scores for social science: Environmental confounding, downward causation, and unknown biology
CH Burt - Behavioral and brain sciences, 2023 - cambridge.org
The sociogenomics revolution is upon us, we are told. Whether revolutionary or not,
sociogenomics is poised to flourish given the ease of incorporating polygenic scores (or …
sociogenomics is poised to flourish given the ease of incorporating polygenic scores (or …
[HTML][HTML] Polygenic scores for social science: Clarification, consensus, and controversy
CH Burt - The Behavioral and brain sciences, 2023 - ncbi.nlm.nih.gov
In this response, I focus on clarifying my arguments, highlighting consensus, and addressing
competing views about the utility of PGSs for social science. I also discuss an assortment of …
competing views about the utility of PGSs for social science. I also discuss an assortment of …
Polygenic Indices (aka Polygenic Scores) in Social Science: A Guide for Interpretation and Evaluation
CH Burt - Sociological Methodology, 2024 - journals.sagepub.com
Polygenic indices (PGI)—the new recommended label for polygenic scores in social science
applications—are genetic summary scales often used to represent an individual's liability for …
applications—are genetic summary scales often used to represent an individual's liability for …
Analysis of Sex-Specific Gene-by-Cohort and Genetic Correlation-by-Cohort Interaction in Educational and Reproductive Outcomes Using the UK Biobank Data
B Zheng, J Fletcher, J Song… - Journal of Health and …, 2023 - journals.sagepub.com
Synthesizing prior gene-by-cohort (G× C) interaction studies, we theorize that changes in
genetic effects by social conditions depend on the level of resource constraints, the …
genetic effects by social conditions depend on the level of resource constraints, the …
[HTML][HTML] Vertical pleiotropy explains the heritability of social science traits
We contend that social science variables are the product of multiple partly heritable traits.
Genetic associations with socio-economic status (SES) may differ across populations, but …
Genetic associations with socio-economic status (SES) may differ across populations, but …
[HTML][HTML] Taking a lifespan approach to polygenic scores
E Freitag, CM Kelsey - The Behavioral and brain sciences, 2023 - ncbi.nlm.nih.gov
This commentary is a call to action for researchers to create and use genome-wide
association studies (GWASs) with previously missed age groups (eg, infancy, elderly), which …
association studies (GWASs) with previously missed age groups (eg, infancy, elderly), which …
[HTML][HTML] From society to cells and back again: new opportunities for discovery at the biosocial interface
A new generation of community-and population-based research is combining measures of
social context, experience, and behavior with direct measures of physiology, gene sequence …
social context, experience, and behavior with direct measures of physiology, gene sequence …
The failure of gene-centrism.
Abstract" Challenging the utility of polygenic scores for social science" is a compelling but
limited critique. Phenotypic development is sensitive to both initial conditions and all …
limited critique. Phenotypic development is sensitive to both initial conditions and all …
Social scientists would do well to steer clear of polygenic scores
D Curtis - Behavioral and Brain Sciences, 2023 - discovery.ucl.ac.uk
The problems with polygenic scores (PGSs) have been understated. The fact that they are
ancestry-specific means that biases related to sociodemographic factors would be …
ancestry-specific means that biases related to sociodemographic factors would be …
GWASs and polygenic scores inherit all the old problems of heritability estimates.
S Sarkar - Behavioral & Brain Sciences, 2023 - search.ebscohost.com
Polygenic score (PGS) computations assume an additive model of gene action because
associations between phenotypes and alleles at different loci are compounded, ignoring …
associations between phenotypes and alleles at different loci are compounded, ignoring …