Oxidative stress-induced myocardial apoptosis is a key step in the pathogenesis of ischemic
heart disease. Calycosin is a phytoestrogen extracted from Radix astragali. In this study, we …

ERβ (oestrogen receptor β) activation has been shown to be cardioprotective, but the cell
types and mechanisms involved are not understood. To investigate whether ERβ restricted …

G protein-coupled estrogen receptor (GPER) is an estrogen receptor expressed in the
cardiovascular system. G1, a selective GPER ligand, exerts cardiovascular effects through …

Objective—To assess the coronary endothelial protective effects of 17β-estradiol (E2) and
the role of estrogen receptor (ER) α in ischemia/reperfusion (I/R). Methods and Results—E2 …

The limited endogenous regenerative capacity of the human heart renders cardiovascular
diseases a major health threat, thus motivating intense research on in vitro heart cell …

Background Cardiac stem cells (CSCs) promote myocardial recovery following ischemia
through their regenerative properties. However, little is known regarding the implication of …

Background Uremic cardiomyopathy is a common cardiovascular complication of chronic
kidney disease (CKD) characterized by left ventricular hypertrophy (LVH) and fibrosis …

We have previously shown that ritonavir (RTV), a highly active anti-retroviral therapy
(HAART) drug, can cause endothelial dysfunction through oxidative stress. Several …

Estrogen receptors are classically known as ligand-activated transcription factors that
regulate gene transcription in cells in response to hormone binding. In addition to this …

Sex differences in responses to myocardial ischemia have been described, but whether
cardiomyocyte function is influenced by sex in the setting of ischemia and reperfusion has …