In the past decade, assays that profile different aspects of the epigenome have grown
exponentially in number and variation. However, standard guidelines for researchers to …

The dynamic epigenetic landscape directs gene expression patterns that dictate cellular
form and function, and drive the assembly of cells into tissues. The high degree of plasticity …

Endocrine‐disrupting chemicals (EDC s) are man‐made chemicals that interfere with
hormonal signalling pathways. They are used in, for example, production of common …

Background: Pediatric obstructive sleep apnea (OSA) leads to multiple end-organ
morbidities that are mediated by the cumulative burden of oxidative stress and inflammation …

Cancer is considered one of the major health issues worldwide, and gastric cancer
accounted for 8% of total cases and 10% of total deaths in 2008. Gastric cancer is …

We previously discovered a novel sirtuin (SIRT) inhibitor, MHY2256, that exerts anticancer
activity through p53 acetylation in MCF-7 human breast cancer cells. We investigated the …

Abstract Model organisms have contributed significantly to the understanding of basic
biological phenomena. Suitable animal models are at hand for some research disciplines …

Exposure to anaesthetic drugs during the fetal or neonatal period induces widespread
neuronal apoptosis in the brains of rodents and non-human primates. Hundreds of …

Understanding how insects will respond both ecologically and evolutionarily to complex and
interacting factors linked to global change is an important challenge that underpins our …

Performance curves of physiological rates are not fixed, and determining the extent to which
thermal performance curves can change in response to environmental signals is essential to …