As of 2017, the World Health Organization has made the recognition, prevention, and
management of sepsis a global health priority. 1 Hippocrates considered the term a …

Acute kidney injury (AKI) is a clinical syndrome that complicates the course and worsens the
outcome in a significant number of hospitalised patients. Recent advances in clinical and …

The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the
1950s and thus did not undergo contemporary drug development procedures. Their clinical …

Kidney disease represents a serious global health problem. One of the main concerns is its
late diagnosis, only feasible in a progressed disease state. The lack of a clinical …

Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

AKI is pathologically characterized by sublethal and lethal damage of renal tubules. Under
these conditions, renal tubular cell death may occur by regulated necrosis (RN) or …

Background Septic shock, a leading cause of acute kidney injury, induces release of pro-
/anti-inflammatory mediators, leading to increased mortality and poor renal recovery. This is …

Objective: Acute kidney injury requiring renal replacement therapy in severe vasodilatory
shock is associated with an unfavorable prognosis. Angiotensin II treatment may help these …

In AKI, dying renal cells release intracellular molecules that stimulate immune cells to
secrete proinflammatory cytokines, which trigger leukocyte recruitment and renal …

Rationale: Sepsis is the cause of nearly half of acute kidney injury (AKI) and, unfortunately,
AKI in sepsis is associated with unacceptably high rates of mortality. Early detection of AKI …