Endoplasmic reticulum stress-mediated autophagy activation is involved in cadmium-induced ferroptosis of renal tubular epithelial cells

C Zhao, D Yu, Z He, L Bao, L Feng, L Chen… - Free Radical Biology …, 2021 - Elsevier
Acute cadmium (Cd) exposure is a significant risk factor for renal injury and lacks effective
treatment strategies. Ferroptosis is a recently identified iron-dependent form of nonapoptotic …

Mitochondrial dysfunction, mitophagy and their correlation with perinatal complications: preeclampsia and low birth weight

RM Yildirim, Y Ergun, M Basar - Biomedicines, 2022 - mdpi.com
Mitochondria are essential organelles and crucial for cellular survival. Mitochondrial
biogenesis and mitophagy are dynamic features that are essential for both maintaining the …

Co-exposure to environmentally relevant concentrations of cadmium and polystyrene nanoplastics induced oxidative stress, ferroptosis and excessive mitophagy in …

W Qiu, J Ye, Y Su, X Zhang, X Pang, J Liao… - Environmental …, 2023 - Elsevier
Nanoplastics (NPs) are defined as a group of emerging pollutants. However, the adverse
effect of NPs and/or heavy metals on mammals is still largely unclear. Therefore, we …

[HTML][HTML] Co-exposure to polystyrene microplastics and lead aggravated ovarian toxicity in female mice via the PERK/eIF2α signaling pathway

Y Feng, H Yuan, W Wang, Y Xu, J Zhang, H Xu… - … and environmental safety, 2022 - Elsevier
Generally, individual microplastics (MPs) or lead (Pb) exposure could initiate ovarian
toxicity. However, their combined effects on the ovary and its mechanism in mammals …

Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig …

L Lu, JB Liu, JQ Wang, CY Lian, ZY Wang… - Environmental Pollution, 2022 - Elsevier
Glyphosate (GLY), one of the most extensively used herbicides in the world, has been
shown to inhibit testosterone synthesis in male animals. Mitochondria are crucial organelles …

Low-dose BPA and its substitute BPS promote ovarian cancer cell stemness via a non-canonical PINK1/p53 mitophagic signaling

X Yuan, K Chen, F Zheng, S Xu, Y Li, Y Wang… - Journal of Hazardous …, 2023 - Elsevier
The environmental toxicity of bisphenol A (BPA) and its analog like bisphenol S (BPS) have
drawn wide attention, but their roles in cancer progression remain controversial. Here, we …

Maternal exposure to trace elements, toxic metals, and longitudinal changes in infancy anthropometry and growth trajectories: a prospective cohort study

X Zhang, H Wei, Q Guan, X Yang, Q Yu… - Environmental …, 2023 - ACS Publications
Exploration of stage-specific effects of maternal exposure to trace elements and toxic metals
on infancy continuous growth and trajectories is critical for early-life health management …

Gestational exposure to environmental cadmium induces placental apoptosis and fetal growth restriction via Parkin-modulated MCL-1 degradation

HL Zhu, LM Dai, YW Xiong, XT Shi, WB Liu… - Journal of Hazardous …, 2022 - Elsevier
Heavy metal cadmium (Cd), a classical environmental pollutant, causes placental apoptosis
and fetal growth restriction (FGR), whereby the mechanism remains unclear. Here, our …

Long-term cadmium exposure induces chronic obstructive pulmonary disease-like lung lesions in a mouse model

WJ Wang, K Peng, X Lu, YY Zhu, Z Li, QH Qian… - Science of The Total …, 2023 - Elsevier
Accumulating evidences demonstrate that long-term exposure to atmospheric fine particles
and air pollutants elevates the risk of chronic obstructive pulmonary disease (COPD) …

Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice

GX Zhou, WB Liu, LM Dai, HL Zhu, YW Xiong… - Science of The Total …, 2022 - Elsevier
Cadmium (Cd) is a well-known testicular toxicant. Blood-testis barrier (BTB), a vital part of
testes, which has been reported to be damaged upon Cd exposure. However, the detailed …