In prostate cancer (PCa), similar to many other cancers, distant organ metastasis symbolizes
the beginning of the end disease, which eventually leads to cancer death. Many …

The HEDGEHOG-GLI (HH-GLI) signalling is a key pathway critical in embryonic
development, stem cell biology and tissue homeostasis. In recent years, aberrant activation …

Metastasis is a predominant cause of death for prostate cancer (PCa) patients; however, the
underlying mechanisms are poorly understood. We report that monoamine oxidase A …

Abstracts Many different genetic alterations, as well as complex epigenetic interactions, are
the basis of the genesis and progression of prostate cancer (CaP). This is the reason why …

Background: Multiple lines of evidence support that the Hedgehog (Hh) signalling has a role
in the maintenance and progression of different human cancers. Therefore, inhibition of the …

Hedgehog (Hh) signaling is a highly conserved intercellular and intracellular communication
mechanism that governs organogenesis and is dysregulated in cancers of numerous …

Cancer metastasis is highly inefficient and complex. Common features of metastatic cancer
cells have been observed using cancer cell lines and genetically reconstituted mouse and …

BACKGROUND Contribution of stromal Hedgehog (Hh) signaling is evident in the prostate
gland in mice, but needs translation to human tissues if Hh therapeutics are to be used …

Abstract Phosphodiesterase 4D (PDE4D) has recently been implicated as a proliferation-
promoting factor in prostate cancer and is overexpressed in human prostate carcinoma …

The last decades have elucidated the genetic basis of pheochromocytoma (PC) and
paraganglioma (PGL)(PCPGL)-associated hereditary syndromes. However, the history of …