Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell
death and survival, playing a pivotal role in multiple interconnected cell signaling …

Background Autophagy is a basic cellular homeostatic process important to cell fate
decisions under conditions of stress. Dysregulation of autophagy impacts numerous human …

Systemic sclerosis (SSc) is a severe auto-immune disease, characterized by vasculopathy
and fibrosis of connective tissues. SSc has a high morbidity and mortality and unfortunately …

Pulmonary fibrosis is characterized by fibroblast proliferation and extracellular matrix
remodelling, leading to respiratory insufficiency. The mechanisms underlying this …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

In a previous study, we isolated human amniotic fluid (AF)-derived mesenchymal stem cells
(AF-MSCs) and utilized normoxic conditioned medium (AF-MSC-norCM) which has been …

Collagen is the most abundant protein in animals. Interactions between tumor cells and
collagen influence every step of tumor development. Type I collagen is the main fibrillar …

Baicalin is an important flavonoid compound THAT is isolated from the Scutellaria
baicalensis Georgi Chinese herb and plays a critical role in anti‑oxidative, anti‑inflammatory …

The pathogenesis of chronic kidney disease (CKD) is complex and apparently multifactorial.
Hypoxia or decrease in oxygen supply in kidney tissues has been implicated in CKD …