Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in
organisms ranging from slime molds to mammals. Central to their function is their ability to …

Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

The acute respiratory distress syndrome (ARDS) is a life-threatening lung condition resulting
from direct and indirect insults to the lung. It is characterized by disruption of the endothelial …

The fundamental role played by neutrophils for an efficient, acute inflammatory response
has long been appreciated, with the underlying molecular and cellular mechanisms largely …

Intercellular transfer of microRNAs can mediate communication between critical effector
cells. We hypothesized that transfer of neutrophil-derived microRNAs to pulmonary epithelial …

Chronic lung diseases represent a major public health problem with only limited therapeutic
options. An important unmet need is to identify compounds and drugs that target key …

The respiratory epithelium is the major interface between the environment and the host.
Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have …

Alveolarization is the process by which the alveoli, the principal gas exchange units of the
lung, are formed. Along with the maturation of the pulmonary vasculature, alveolarization is …

Epithelial permeability is a hallmark of mucosal inflammation, but the molecular mechanisms
involved remain poorly understood. A key component of the epithelial barrier is the apical …

Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …