Insights into distinct signaling profiles of the µOR activated by diverse agonists
Drugs targeting the μ-opioid receptor (μOR) are the most effective analgesics available but
are also associated with fatal respiratory depression through a pathway that remains …
are also associated with fatal respiratory depression through a pathway that remains …
An update on the clinical pharmacology of kratom: uses, abuse potential, and future considerations
ABSTRACT Introduction Kratom (Mitragyna speciosa) has generated substantial clinical and
scientific interest as a complex natural product. Its predominant alkaloid mitragynine and …
scientific interest as a complex natural product. Its predominant alkaloid mitragynine and …
[HTML][HTML] IUPHAR themed review: Opioid efficacy, bias, and selectivity
N Ramos-Gonzalez, B Paul, S Majumdar - Pharmacological research, 2023 - Elsevier
Drugs acting at the opioid receptor family are clinically used to treat chronic and acute pain,
though they represent the second line of treatment behind GABA analogs, antidepressants …
though they represent the second line of treatment behind GABA analogs, antidepressants …
Structure-based design of bitopic ligands for the µ-opioid receptor
Mu-opioid receptor (µOR) agonists such as fentanyl have long been used for pain
management, but are considered a major public health concern owing to their adverse side …
management, but are considered a major public health concern owing to their adverse side …
[HTML][HTML] The chemical and pharmacological properties of mitragynine and its diastereomers: an insight review
T Karunakaran, KZ Ngew, AAD Zailan… - Frontiers in …, 2022 - frontiersin.org
Mitragynine, is a naturally occurring indole alkaloid that can be isolated from the leaves of a
psychoactive medicinal plant. Mitragyna speciosa, also known as kratom, is found to …
psychoactive medicinal plant. Mitragyna speciosa, also known as kratom, is found to …
Interactive effects of µ-opioid and adrenergic-α2 receptor agonists in rats: pharmacological investigation of the primary kratom alkaloid mitragynine and its metabolite 7 …
The primary kratom alkaloid mitragynine is proposed to act through multiple mechanisms,
including actions at µ-opioid receptors (MORs) and adrenergic-α 2 receptors (A α 2Rs), as …
including actions at µ-opioid receptors (MORs) and adrenergic-α 2 receptors (A α 2Rs), as …
Methodological Development and Applications of Tryptamine-Ynamide Cyclizations in Synthesizing Core Skeletons of Indole Alkaloids
L Yang, A Hou, Q Jiang, M Cheng… - The Journal of Organic …, 2023 - ACS Publications
Over the past two decades, synthetic strategies for synthesizing the skeletons of various
indole alkaloids based on tryptamine-ynamide have been continuously developed and …
indole alkaloids based on tryptamine-ynamide have been continuously developed and …
Translating kratom-drug interactions: from bedside to bench and back
Kratom is a botanical natural product belonging to the coffee family, with stimulant effects at
low doses and opioid-like effects at higher doses. During the last two decades, kratom has …
low doses and opioid-like effects at higher doses. During the last two decades, kratom has …
Opioid signaling and design of analgesics
B Paul, S Sribhashyam, S Majumdar - Progress in molecular biology and …, 2023 - Elsevier
Clinical treatment of acute to severe pain relies on the use of opioids. While their potency is
significant, there are considerable side effects that can negatively affect patients. Their rise …
significant, there are considerable side effects that can negatively affect patients. Their rise …
[HTML][HTML] An insight review on the neuropharmacological effects, mechanisms of action, pharmacokinetics and toxicity of mitragynine
NAK Annuar, UK Azlan, A Mediani, X Tong… - Biomedicine & …, 2024 - Elsevier
Mitragynine is one of the main psychoactive alkaloids in Mitragyna speciosa Korth.(kratom).
It has opium-like effects by acting on μ-, δ-, and κ-opioid receptors in the brain. The …
It has opium-like effects by acting on μ-, δ-, and κ-opioid receptors in the brain. The …