Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments

L Zuo, ER Prather, M Stetskiv, DE Garrison… - International journal of …, 2019 - mdpi.com
It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …

IL-17 cytokines and chronic lung diseases

F Ritzmann, LP Lunding, R Bals, M Wegmann… - Cells, 2022 - mdpi.com
IL-17 cytokines are expressed by numerous cells (eg, gamma delta (γδ) T, innate lymphoid
(ILC), Th17, epithelial cells). They contribute to the elimination of bacteria through the …

Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments

L Zuo, F He, GG Sergakis… - … of Physiology-Lung …, 2014 - journals.physiology.org
Cigarette smoking (CS) can impact the immune system and induce pulmonary disorders
such as chronic obstructive pulmonary disease (COPD), which is currently the fourth leading …

Cytokine inhibition in the treatment of COPD

G Caramori, IM Adcock, A Di Stefano… - International journal of …, 2014 - Taylor & Francis
Cytokines play an important part in many pathobiological processes of chronic obstructive
pulmonary disease (COPD), including the chronic inflammatory process, emphysema, and …

B cells in chronic obstructive pulmonary disease: moving to center stage

F Polverino, LJM Seys, KR Bracke… - American Journal of …, 2016 - journals.physiology.org
Chronic inflammatory responses in the lungs contribute to the development and progression
of chronic obstructive pulmonary disease (COPD). Although research studies focused …

Chronic obstructive pulmonary disease alters immune cell composition and immune checkpoint inhibitor efficacy in non–small cell lung cancer

NM Mark, J Kargl, SE Busch, GHY Yang… - American Journal of …, 2018 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) and non–small cell lung cancer
(NSCLC) are interrelated diseases with substantial mortality, and the pathogenesis of both …

Th17 cytokines: novel potential therapeutic targets for COPD pathogenesis and exacerbations

O Le Rouzic, M Pichavant, E Frealle… - European …, 2017 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the
airways caused mainly by cigarette smoke exposure. COPD progression is marked by …

Epithelium-derived IL17A Promotes Cigarette Smoke–induced Inflammation and Mucus Hyperproduction

M Wu, T Lai, D Jing, S Yang, Y Wu, Z Li… - American journal of …, 2021 - atsjournals.org
The airway epithelium is a central modulator of innate and adaptive immunity in the lung.
IL17A expression was found to be increased in the airway epithelium; however, the role of …

Association between IL-17 and Chronic Obstructive Pulmonary Disease: a systematic review and Meta-analysis

R Ma, H Su, K Jiao, J Liu - International Journal of Chronic …, 2023 - Taylor & Francis
Background Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory
disease characterized by neutrophils airway infiltration. It is currently known that Interleukin …

Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette-smoke-induced lung inflammation in mice

S Bozinovski, HJ Seow, SPJ Chan, D Anthony… - Clinical …, 2015 - portlandpress.com
Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD).
Interleukin-17A (IL-17A) is a pivotal cytokine that regulates lung immunity and inflammation …