Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …

Neuropathic pain refers to pain that originates from pathology of the nervous system.
Diabetes, infection (herpes zoster), nerve compression, nerve trauma, and autoimmune …

Accumulating evidence indicates that purinergic P2X4 receptors (P2X4R: cation channels
activated by extracellular ATP) expressed in spinal microglia are crucial for pathological …

Injury to the nerve can produce changes in dorsal horn function and pain. This facilitated
processing may be mediated in part by voltage-sensitive calcium channels. Activation of …

Animal models of chronic pain serve as an experimental basis for testing new therapeutic
interventions and for mechanistic investigations. In an animal model of chronic pain, based …

Herpetic‐related neuralgia (HN) caused by varicella‐zoster virus (VZV) infection is one of
the most typical and common neuropathic pain in the clinic. However, the potential …

Chemotherapy-induced peripheral neuropathy is a common, dose-limiting side effect of
cancer chemotherapeutic agents, including the vinca alkaloids such as vincristine. The …

Herpetic neuralgia is the most important symptom of herpes zoster disease, which is caused
by Varicella zoster. Nevertheless, the pathophysiological mechanisms involved in herpetic …

Chronic pain affects approximately 20% of people worldwide and places a large economic
and social burden on society. Despite the availability of a range of analgesics, this condition …

Herpetic neuralgia is a painful condition following herpes zoster disease, which results from
Varicella-zoster virus reactivation in the dorsal or trigeminal sensory ganglia. Nevertheless …