Short Chain Fatty Acids: Fundamental mediators of the gut-lung axis and their involvement in pulmonary diseases

S Ashique, G De Rubis, E Sirohi, N Mishra… - Chemico-biological …, 2022 - Elsevier
The human microbiota is fundamental to correct immune system development and balance.
Dysbiosis, or microbial content alteration in the gut and respiratory tract, is associated with …

[HTML][HTML] The impact of microbiota-derived short-chain fatty acids on macrophage activities in disease: Mechanisms and therapeutic potentials

H Duan, LJ Wang, M Huangfu, H Li - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Short-chain fatty acids (SCFAs) derived from the fermentation of carbohydrates by gut
microbiota play a crucial role in regulating host physiology. Among them, acetate …

Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease severity in hamsters

V Sencio, A Machelart, C Robil, N Benech… - Gut …, 2022 - Taylor & Francis
Mounting evidence suggests that the gut-to-lung axis is critical during respiratory viral
infections. We herein hypothesized that disruption of gut homeostasis during severe acute …

Role of short-chain fatty acids produced by gut microbiota in innate lung immunity and pathogenesis of the heterogeneous course of chronic obstructive pulmonary …

S Kotlyarov - International Journal of Molecular Sciences, 2022 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a widespread socially significant disease.
The development of COPD involves the innate immune system. Interestingly, the regulation …

Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1α Axis

MG Machado, TA Patente, Y Rouillé, S Heumel… - Frontiers in …, 2022 - frontiersin.org
Short-chain fatty acids (SCFAs) are metabolites produced mainly by the gut microbiota with
a known role in immune regulation. Acetate, the major SCFA, is described to disseminate to …

Gut colonisation with multidrug-resistant Klebsiella pneumoniae worsens Pseudomonas aeruginosa lung infection

R Le Guern, T Grandjean, S Stabler, M Bauduin… - Nature …, 2023 - nature.com
Carbapenemase-producing Enterobacterales (CPE) are spreading rapidly in hospital
settings. Asymptomatic CPE gut colonisation may be associated with dysbiosis and gut-lung …

Ingestion, immunity, and infection: nutrition and viral respiratory tract infections

C Govers, PC Calder, HFJ Savelkoul, R Albers… - Frontiers in …, 2022 - frontiersin.org
Respiratory infections place a heavy burden on the health care system, particularly in the
winter months. Individuals with a vulnerable immune system, such as very young children …

[HTML][HTML] Microbial metabolite dysbiosis and colorectal cancer

P Niekamp, CH Kim - Gut and Liver, 2023 - ncbi.nlm.nih.gov
The global burden of colorectal cancer (CRC) is expected to continuously increase. Through
research performed in the past decades, the effects of various environmental factors on CRC …

[HTML][HTML] Anticancer effects of gut microbiota-derived short-chain fatty acids in cancers

MY Son, HS Cho - Journal of Microbiology and Biotechnology, 2023 - ncbi.nlm.nih.gov
Short-chain fatty acids (SCFAs), such as butyrate, propionate, and acetate produced by the
gut microbiota have been implicated in physiological responses (defense mechanisms …

The role of microbiota-derived postbiotic mediators on biofilm formation and quorum sensing-mediated virulence of Streptococcus mutans: A perspective on …

E OmerOglou, B Karaca, H Kibar, O Haliscelik… - Microbial …, 2022 - Elsevier
Dental caries is not only one of the most prevalent diseases worldwide, but also a public
health problem, undoubtedly. Among the various species of cariogenic bacteria …