The fusogenic potential of Class I viral envelope glycoproteins is activated by proteloytic
cleavage of the precursor glycoprotein to generate the mature receptor-binding and …

This chapter presents an overview of cell entry by nidoviruses, and focuses on the
functioning of the coronavirus fusion protein, in particular, on its proteolytic cleavage …

The hexameric α-helical coiled-coil formed between the C-terminal and N-terminal heptad
repeat (CHR and NHR) regions of class I viral fusion proteins plays an important role in …

The peptides derived from the heptad repeat (HRP) of severe acute respiratory syndrome
coronavirus (SCoV) spike protein (sHRPs) are known to inhibit SCoV infection, yet their …

The Spike (S) glycoprotein of coronaviruses (CoV) mediates viral entry into host cells. It
contains two hydrophobic heptad repeat (HR) regions, denoted HRN and HRC, which …

To understand the roles of heptad repeat 1 (HR1) and HR2 of the spike (S) protein of the
severe acute respiratory syndrome coronavirus (SARS-CoV) in virus-cell interactions, the …

Hexameric structure formation through packing of three C-terminal helices and an N-
terminal trimeric coiled-coil core has been proposed as a general mechanism of class I …

SARS‐CoV spike (S) protein‐mediated cell fusion is important for the viral entry mechanism
and identification of SARS‐CoV entry inhibitors. In order to avoid the high risks involved in …

Both the deep pocket region and its neighboring subpocket site on the N-trimer of HIV-1
gp41 protein can serve as targets for the development of HIV-1 entry inhibitors. Pocket …

MATERIALS AND METHODS Cells and antibodies. Human embryonic kidney 293T and
Vero E6 cells were cultured in Dulbecco's modified Eagle's medium supplemented with 10 …