Pathogenic bacteria infection is a major public health problem due to the high morbidity and
mortality rates, as well as the increased expenditure on patient management. Although there …

As one of the most promising and effective delivery systems for targeted controlled-release
drugs, nanocarriers (NCs) have been widely studied. Although the development of …

Tetrahedral framework nucleic acids (tFNAs) have attracted extensive attention as drug
nanocarriers because of their excellent cellular uptake. However, for oligonucleotide cargos …

Sepsis is one of the leading causes of death worldwide with high mortality rates and a
pathological complexity hindering early and accurate diagnosis. Today, laboratory culture …

Nucleic acid drugs have the advantages of rich target selection, simple in design, good and
enduring effect. They have been demonstrated to have irreplaceable superiority in brain …

Ischemia-reperfusion (IR) injury represents a major cause of myocardial dysfunction after
infarction and thrombolytic therapy, and it is closely related to the free radical explosion and …

Cell surface protein–carbohydrate interactions are essential for tissue-specific recognition
and endocytosis of viruses, some bacteria and their toxins, and many glycoproteins. Often …

Abstract mRNA gene therapy has recently emerged as a candidate to enable multiple
therapeutic applications including protein replacement therapy, vaccine immunology, and …

Cancer vaccines have attracted increasing attention for their application in tumor
immunotherapy. DNA vaccines are one of them that have been proven very promising with …

Microglia polarization plays an important role in poststroke recovery. Inhibition of
proinflammatory (M1) polarization and promotion of anti-inflammatory (M2) polarization of …