The introduction of antifungals in clinical practice has an enormous impact on the provision
of medical care, increasing the expectancy and quality of life mainly of immunocompromised …

Candida spp. can adhere to and form biofilms over different surfaces, becoming less
susceptible to antifungal treatment. Resistance of biofilms to antifungal agents is …

The rapid emergence of multidrug resistant microorganisms has become one of the most
critical threats to public health. A decrease in the effectiveness of available antibiotics has …

Aspergillus terreus is an emerging fungal pathogen in immunocompromised patients. Due to
the intrinsic resistance of AmB against A. terreus and acquiring resistance to azoles, an …

Currently, multidrug-resistant (MDR) infections are one of the most important threats, driving
the search for new antimicrobial compounds. Cationic peptide antibiotics (CPAs) and …

Schiff bases (SBs) are chemical compounds displaying a significant pharmacological
potential. They are able to modulate the activity of many enzymes involved in metabolism …

Paracoccidioidomycosis is a neglected disease that causes economic and social impacts,
mainly affecting people of certain social segments, such as rural workers. The limitations of …

Invasive fungal infections caused by opportunistic fungal pathogens are associated with
high mortality rates, mainly due to the occurrence of genotypic and/or phenotypic resistance …

Candida albicans is the most common human fungal pathogen in immunocompromised
individuals. With the emergence of clinical fungal resistance, there is an urgent need to …

Systemic candidiasis is a growing health care concern that is becoming even more
challenging due to the growing frequency of infections caused by multidrug-resistant (MDR) …