Electric and hybrid vehicles are associated with green technologies and a reduction in
greenhouse emissions due to their low emissions of greenhouse gases and fuel-economic …

Lysosomes are acidic compartments filled with more than 60 different types of hydrolases.
They mediate the degradation of extracellular particles from endocytosis and of intracellular …

Sleep is conserved from invertebrates to vertebrates, and is tightly regulated in a
homeostatic manner. The molecular and cellular mechanisms that determine the amount of …

Survival in the wild requires organismal adaptations to the availability of nutrients.
Endosomes and lysosomes are key intracellular organelles that couple nutrition and …

Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …

Opioid-induced respiratory depression (OIRD) represents the primary cause of death
associated with therapeutic and recreational opioid use. Within the United States, the rate of …

Diverticular disease is a common clinical problem, particularly in industrialized countries. In
most cases, colonic diverticula remain asymptomatic throughout life and sometimes are …

Lysosomes play fundamental roles in material digestion, cellular clearance, recycling,
exocytosis, wound repair, Ca2+ signaling, nutrient signaling, and gene expression …

The physiological function and molecular regulation of plasma membrane potential have
been extensively studied, but how intracellular organelles sense and control membrane …

An intact kidney filter is vital to retention of essential proteins in the blood and removal of
waste from the body. Damage to the filtration barrier results in albumin loss in the urine, a …