Chronic myeloid leukemia (CML) is caused by Bcr-Abl, an activated tyrosine kinase. The
amounts of Bcr-Abl mRNA and protein in cells from patients in blast crisis (BC) are higher …

Abstract Background Chronic Myeloid Leukaemia (CML) is caused by the BCR/ABL1 fusion
gene. Both the presence and the levels of BCR/ABL1 expression seem to be critical for CML …

Chronic Myeloid Leukemia (CML) is a disease of hematopoietic stem cells which harbor the
chimeric gene Bcr‐Abl. Expression levels of this constitutively active tyrosine kinase are …

Chronic myelogenous leukemia (CML) is a malignant disease characterized by expression
of p210-BCR-ABL, the product of the Philadelphia chromosome. Survival of CML patients …

The WT1 gene is expressed in 73–100% of patients with acute myelogenous leukemia
(AML) and is thought to play a role in maintaining the viability of leukemic cells. WT1 has …

Chronic myeloid leukemia (CML) is typified by robust marrow and extramedullary myeloid
cell production. In the absence of therapy or sometimes despite it, CML has a propensity to …

Deletions of the derivative chromosome 9 have recently been reported in chronic myeloid
leukemia. These deletions are large, occur at the time of the Philadelphia (Ph) translocation …

Abstract Increased levels of Bcr-Abl expression in chronic myelogenous leukemia (CML)
cells are associated with disease progression and imatinib (IM) resistance. However, it is not …

Chronic myeloid leukemia (CML) and some acute lymphoblastic leukemias are
characterized by the t (9; 22) chromosome, which encodes the BCR/ABL oncogene. Multiple …

With an annual incidence of about ten in 1,000,000 people, chronic myeloid leukemia (CML)
accounts for most cases of myeloproliferative disease and for 20% of all leukemias. While …