Disruption of autophagy plays an import role in neurodegenerative disorders, where
deficient elimination of abnormal and toxic protein aggregates promotes cellular stress …

Selective autophagy of mitochondria, known as mitophagy, is an important mitochondrial
quality control mechanism that eliminates damaged mitochondria. Mitophagy also mediates …

Autophagy is a self‐degradative process that is important for balancing sources of energy at
critical times in development and in response to nutrient stress. Autophagy also plays a …

Reactive oxygen species (ROS) are small and highly reactive molecules that can oxidize
proteins, lipids and DNA. When tightly controlled, ROS serve as signaling molecules by …

Introduction• Protein aggregation‐'Toxic oligomer'hypothesis‐Protein (mis) folding‐
Proteostasis and molecular chaperones‐Protein misfolding and endoplasmic reticulum …

Mutations in PTEN-induced kinase 1 (PINK1) cause early onset autosomal recessive
Parkinson's disease (PD). PINK1 is a 63 kDa protein kinase, which exerts a neuroprotective …

Autophagy is an intracellular degradation process that clears long-lived proteins and
organelles from the cytoplasm. It involves the formation of double-membraned structures …

Autophagy is a major catabolic pathway in eukaryotes, which is required for the
lysosomal/vacuolar degradation of cytoplasmic proteins and organelles. Interest in the …

Efficient degradation of autophagic vacuoles (AVs) via lysosomes is an important cellular
homeostatic process. This is particularly challenging for neurons because mature acidic …

Many studies have reported the roles played by regulated proteolysis in synaptic plasticity
and memory, but the role of autophagy in neurons remains unclear. In mammalian cells …