In recent years, DNA has emerged as a fascinating building material to engineer hydrogel
due to its excellent programmability, which has gained considerable attention in biomedical …

Conspectus The ultimate limit of analytical chemistry is single-molecule detection, which
allows one to visualize the dynamic processes of chemical/biological interactions with single …

Cells interact with the extracellular environment through molecules expressed on the
membrane. Disruption of these membrane-bound interactions (or encounters) can result in …

The advent of molecular tension probes for real-time mapping of piconewton forces in living
systems has had a major impact on mechanobiology. For example, DNA-based tension …

Sequence analogs of human telomeric DNA such as d [AGGG (TTAGGG) 3](Tel22) fold into
monomeric quadruplex structures in the presence of a suitable cation. To investigate the …

Controlling biological molecular processes with light is of interest in biological research and
biomedicine, as light allows precise and selective activation in a non‐invasive and non‐toxic …

The transition of single-molecule fluorescence detection and imaging from in vitro to living
cells has greatly enriched our knowledge on the behavior of single biomolecules in their …

Supramolecular hydrogels display unique dynamic features such as self-healing and
injectability which are endowed by their non-covalent crosslinking. These extraordinary …

Hydrogels have been widely applied to understand the fundamental functions and
mechanism of a natural extracellular matrix (ECM). However, revealing the high permeability …

A robust understanding of the sequence-dependent thermodynamics of DNA hybridization
has enabled rapid advances in DNA nanotechnology. A fundamental understanding of the …