The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease

YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Ageing research reviews, 2020 - Elsevier
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and it is
characterised by progressive deterioration in cognitive and memory abilities, which can …

PM2. 5 exposure in association with AD-related neuropathology and cognitive outcomes

K Thiankhaw, N Chattipakorn, SC Chattipakorn - Environmental Pollution, 2022 - Elsevier
Particulate matter with a diameter of less than 2.5 μm or PM2. 5 is recognized worldwide as
a cause of public health problems, mainly associated with respiratory and cardiovascular …

Exposure to polystyrene microplastics triggers lung injury via targeting toll-like receptor 2 and activation of the NF-κB signal in mice

J Cao, R Xu, Y Geng, S Xu, M Guo - Environmental Pollution, 2023 - Elsevier
Microplastics are ubiquitous pollutants with a wide range of plastic applications. More
recently, microplastics are in the air and can be inhaled into the lungs, causing respiratory …

An air particulate pollutant induces neuroinflammation and neurodegeneration in human brain models

YJ Kang, HY Tan, CY Lee, H Cho - Advanced Science, 2021 - Wiley Online Library
Abstract Fine particulate matter (PM2. 5), a major component among air pollutants,
highlights as a global health concern. Several epidemiological studies show the correlation …

Role of environmental toxicants on neurodegenerative disorders

M Nabi, N Tabassum - Frontiers in toxicology, 2022 - frontiersin.org
Neurodegeneration leads to the loss of structural and functioning components of neurons
over time. Various studies have related neurodegeneration to a number of degenerative …

Modulatory mechanisms of the NLRP3 inflammasomes in diabetes

S Ding, S Xu, Y Ma, G Liu, H Jang, J Fang - Biomolecules, 2019 - mdpi.com
The inflammasome is a multiprotein complex that acts to enhance inflammatory responses
by promoting the production and secretion of key cytokines. The best-known inflammasome …

PM2. 5‐induced pulmonary inflammation via activating of the NLRP3/caspase‐1 signaling pathway

H Jia, Y Liu, D Guo, W He, L Zhao… - Environmental …, 2021 - Wiley Online Library
Abstract Particulate matter 2.5 (PM2. 5)‐induced pulmonary inflammation has become a
public concern in recent years. In which, the activation of the NLRP3/caspase‐1 pathway …

[HTML][HTML] Advanced human developmental toxicity and teratogenicity assessment using human organoid models

M Li, J Gong, L Gao, T Zou, J Kang, H Xu - … and Environmental Safety, 2022 - Elsevier
Tremendous progress has been made in the field of toxicology leading to the advance of
developmental toxicity assessment. Conventional animal models and in vitro two …

Environmental factors and risk of gout

ZD Wu, XK Yang, YS He, J Ni, J Wang, KJ Yin… - Environmental …, 2022 - Elsevier
Gout is a chronic disease with inflammatory arthritis caused by monosodium urate (MSU)
crystals deposition, an elevated serum urate level (hyperuricaemia) is the critical factor …

Overview of PM2. 5 and health outcomes: focusing on components, sources, and pollutant mixture co-exposure

N Nan, Z Yan, Y Zhang, R Chen, G Qin, N Sang - Chemosphere, 2023 - Elsevier
PM 2.5 varies in source and composition over time and space as a complicated mixture.
Consequently, the health effects caused by PM 2.5 varies significantly over time and …