No juvenile arterial hypertension in sheep multiples despite reduced nephron numbers

A Mühle, C Mühle, K Amann, J Dötsch, KD Nüsken… - Pediatric …, 2010 - Springer
Low birth weight is associated with an increased risk of metabolic dysfunction and arterial
hypertension in later life. Because of their reduced birth weight twins have been used …

Uteroplacental insufficiency increases p53 phosphorylation without triggering the p53-MDM2 functional circuit response in the IUGR rat kidney

M Baserga, MA Hale, X Ke, ZM Wang… - American Journal …, 2006 - journals.physiology.org
Uteroplacental insufficiency (UPI) leads to intrauterine growth restriction (IUGR), which
predisposes infants toward renal insufficiency early in life and increases the risk of kidney …

[HTML][HTML] A stereological and electron microscopic study of the development of the nephron in prenatal and postnatal rats

N Şimşek, BZ Altunkaynak, D Ünal, S Can… - The eurasian journal …, 2009 - ncbi.nlm.nih.gov
Objective To describe the morphometric and ultra-structural features of the kidney in fetal (20-
day-old), newborn (7-day-old) and adult (180-day-old) rats. Materials and Methods Kidneys …

Chronic intrauterine exposure to endotoxin does not alter fetal nephron number or glomerular size

D Ryan, A Atik, R De Matteo… - Clinical and …, 2013 - Wiley Online Library
A reduced nephron endowment early in life adversely impacts on long‐term functional
reserve in the kidney. A recent study has shown that acute exposure to chorioamnionitis …

The perinatal development of arterial pressure in sheep: effects of low birth weight due to twinning

R De Matteo, V Stacy, M Probyn, M Desai, M Ross… - Reproductive …, 2008 - Springer
The aim of this study is to determine the effect of fetal growth restriction due to twinning on
the perinatal development of arterial pressure. Arterial pressure was recorded in fetal sheep …

A practical guide to the stereological assessment of glomerular number, size, and cellular composition

MR Sutherland, D Vojisavljevic… - The Anatomical …, 2020 - Wiley Online Library
The evaluation of a range of measures in the kidneys, such as developmental stage, rate
and success, injury, and disease processes, relies on obtaining information on the three …

Ovine fetal renal development impacted by multiple fetuses and uterine space restriction

KM Meyer-Gesch, MY Sun, JM Koch… - … origins of health and …, 2013 - cambridge.org
Intrauterine growth restriction (IUGR) from uteroplacental dysfunction causes impaired
nephrogenesis and ultimately hypertension, but it is unknown whether IUGR caused by …

Glomerular hypertrophy in offspring of subtotally nephrectomized ewes

AE Brandon, AC Boyce, ER Lumbers… - … Record: Advances in …, 2008 - Wiley Online Library
We have shown that fetuses whose mothers underwent subtotal nephrectomy (STNx) before
pregnancy had high urine flow rates and sodium excretions, but lower hematocrits, plasma …

Does extreme prematurity affect kidney volume at term corrected age?

AL Kent, R Jyoti, C Robertson… - The Journal of …, 2009 - Taylor & Francis
Objective. Extreme prematurity exposes the neonate to a number of potential renal insults
that may result in a reduced number of glomeruli and/or renal size. This may predispose …

Kidney growth in twin children born small for gestational age

V Giapros, A Drougia, E Hotoura… - Nephrology Dialysis …, 2010 - academic.oup.com
Background. Low birth weight (LBW) is associated with adult-onset diseases, including
hypertension and renal disease; altered renal development after intrauterine growth …