Synthesis and characterization of thermally responsive pluronic F127− chitosan nanocapsules for controlled release and intracellular delivery of small molecules

W Zhang, K Gilstrap, L Wu, RB KC, MA Moss, Q Wang… - ACS …, 2010 - ACS Publications
In this study, we synthesized empty core− shell structured nanocapsules of Pluronic F127
and chitosan and characterized the thermal responsiveness of the nanocapsules in size and …

The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic

R Scatena, P Bottoni, G Botta… - … of physiology-cell …, 2007 - journals.physiology.org
In addition to their well-known critical role in energy metabolism, mitochondria are now
recognized as the location where various catabolic and anabolic processes, calcium fluxes …

[HTML][HTML] Approaches for targeting mitochondria in cancer therapy

GGM D'Souza, MA Wagle, V Saxena, A Shah - Biochimica et Biophysica …, 2011 - Elsevier
The recognition of the role that mitochondria play in human health and disease is evidenced
by the emergence in recent decades of a whole new field of “Mitochondrial Medicine” …

Dye-labelled polymer chains at specific sites: Synthesis by living/controlled polymerization

M Beija, MT Charreyre, JMG Martinho - Progress in polymer science, 2011 - Elsevier
Dye-labelled polymer chains are extremely useful in many fields, such as optical imaging,
signal amplification in biological diagnostics, light-harvesting and photochromic materials as …

Triphenylphosphonium‐conjugated poly (ε‐caprolactone)‐based self‐assembled nanostructures as nanosized drugs and drug delivery carriers for mitochondria …

DY Cho, H Cho, K Kwon, M Yu, E Lee… - Advanced Functional …, 2015 - Wiley Online Library
For mitochondria‐targeting delivery, a coupling reaction between poly (ε‐caprolactone) diol
(PCL diol) and 4‐carboxybutyltriphenylphosphonium (4‐carboxybutyl TPP) results in the …

Single particle orientation and rotation tracking discloses distinctive rotational dynamics of drug delivery vectors on live cell membranes

Y Gu, W Sun, G Wang, N Fang - Journal of the American Chemical …, 2011 - ACS Publications
Engineered nanoparticles have emerged as potentially revolutionary drug and gene
delivery vectors. Using rod-shaped gold nanoparticles as a model, we studied for the first …

Near-infrared light-triggered drug-delivery vehicle for mitochondria-targeted chemo-photothermal therapy

E Ju, Z Li, Z Liu, J Ren, X Qu - ACS applied materials & interfaces, 2014 - ACS Publications
A novel drug-delivery vehicle for mitochondria-targeted chemo-photothermal therapy was
demonstrated. A cytochrome c-specific binding aptamer was employed to make the …

Straightforward route to superhydrophilic poly (2-oxazoline) s via acylation of well-defined polyethylenimine

O Sedlacek, O Janouskova, B Verbraeken… - …, 2018 - ACS Publications
Herein, we describe a new method for the synthesis of superhydrophilic poly (2-alkyl-2-
oxazoline) s (PAOx) from poly (2-ethyl-2-oxazoline)(PEtOx). A well-defined linear …

Understanding nano-bio interactions to improve nanocarriers for drug delivery

RM Pearson, H Hsu, J Bugno, S Hong - Mrs Bulletin, 2014 - cambridge.org
The ability of cancer-targeted nanoparticles (NPs) to reach their site of action and evoke a
desired biological response after intravenous injection is critical to achieve clinically …

Enhanced photodynamic efficiency achieved via a dual-targeted strategy based on photosensitizer/micelle structure

J Xu, F Zeng, H Wu, C Hu, S Wu - Biomacromolecules, 2014 - ACS Publications
The applications of photodynamic therapy (PDT) are usually limited by photosensitizer's side
effect and the singlet oxygen's short half-life. Herein, we demonstrate a dual-targeting (both …