The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery
of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a …

A highly persistent trace environmental contaminant and one of the most potent toxicants
known is dioxin (2, 3, 7, 8-tetrachlorodibenzo-para-dioxin or TCDD). TCDD induces a broad …

In CKD, uremic solutes may induce endothelial dysfunction, inflammation, and oxidative
stress, leading to increased cardiovascular risk. We investigated whether the uremic solute …

Recent studies have shown an association between maternal exposure to ambient fine
particle matter (PM2. 5) and congenital heart defects in the offspring, but the underlying …

Systematic consideration of scientific support is a critical element in developing and,
ultimately, using adverse outcome pathways (AOPs) for various regulatory applications …

The prevalence of obesity has increased dramatically during the past decades, which has
been a major health problem. Since 1975, the number of people with obesity worldwide has …

Polyamines are small organic polycations that are absolutely required for cell growth and
proliferation; yet the basis for this requirement is mostly unknown. Here, we combined a …

Gut microbiota in interaction with intestinal host tissues influences many brain functions and
microbial dysbiosis has been linked with brain disorders, such as neuropsychiatric …

The Ah receptor (AHR) has been studied for almost five decades. Yet, we still have many
important questions about its role in normal physiology and development. Moreover, we still …

The antagonistic pleiotropy hypothesis is a well-known evolutionary theory to explain the
aging process. It proposes that while a particular gene may possess beneficial effects during …