Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

Alzheimer's disease (AD) is a neurodegenerative disease with cognitive impairment.
Oxidative stress in neurons is considered as a reason for development of AD. Antioxidant …

In the current study, a series of fluorine-substituted piperidine derivatives (1–8) has been
synthesized and characterized by various spectroscopic techniques. In vitro and in vivo …

Nature-inspired, bridged polycyclic molecules share low similarity with currently available
drugs, containing preferentially planar and/or achiral moieties. This “Escape from Flatland” …

Designing small molecule inhibitors targeting cholinesterases (ChEs) is considered as an
efficient strategy for the treatment of Alzheimer′ s disease (AD). In the present study, based …

A new series of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors
were designed based on the structure of tacrine and synthesized in multicomponent …

Alzheimer's disease (AD) is a neurological illness that develops over time. Although the
disease's origin and pathophysiology remain unclear, acetylcholinesterase (AChE) has …

Materials and Methods: Two 7-morpholinoethoxyhomoisoflavonoids synthesized via three
steps including SN 2 reaction of 7-hydroxychromanine with morpholino ethyl chloride …

Alzheimer's disease (AD) is a neurodegenerative disease with cognitive impairment.
Oxidative stress in neurons is considered as a reason for development of AD. Antioxidant …