Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

Major depressive disorder (MDD) is a disease associated with many factors; specifically,
environmental, genetic, psychological, and biological factors play critical roles. Recent …

Background Traditional radiotherapy and chemotherapy have been intensively studied for
their role in the treatment of tumours. However, these therapies often cause side effects for …

Abstract Background Paeonia lactiflora Pall.(PL) is widely used in China as a homologous
plant of medicine and food. PL flower is rich in bioactive substances with anti-inflammatory …

The repressor element 1 silencing transcription factor (REST) has been proposed to function
as a transcription factor to silence gene transcription by binding to repressor element 1 …

A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and, as such,
provides a semi-selective barrier between the blood and the interstitial space. Compromise …

Histone deacetylase 1 (HDAC1) is a unique member of the classes I HDACs and helps to
regulate acute and chronic adaptation to environmental stimuli such as allergen, stress …

Influenza virus has the ability to circumvent host innate immune system through regulating
certain host factors for its effective propagation. However, the detailed mechanism is still not …

Histone deacetylase 6 (HDAC6) plays a crucial role in the acetylation of non-histone
proteins and is notably implicated in angiogenesis, though its underlying mechanisms were …

Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of
various malignancies and have garnered attention as a viable target for therapeutic …