Current approaches for topical vaginal administration of nanoparticles result in poor
retention and extensive leakage. To overcome these challenges, we developed a …

The relationship between the intestines and their microbiota, the liver, and the neuronal
system is called the gut-liver-brain axis. This relationship has been studied and observed for …

Antibodies that specifically bind polyethylene glycol (PEG) can lead to rapid elimination of
PEGylated therapeutics from the systemic circulation. We have recently shown that virus …

Highlights•Mucus model has a strong influence on the results of mucus diffusion
studies.•Experimental conditions during diffusion studies have to be controlled.• …

Here, we present a microfluidics chip platform which allows for studying the charge-
dependent transport of molecules across the interface of acidic mucin gels. With this setup …

At the onset of pregnancy, people with preexisting conditions face additional challenges in
carrying their pregnancy to term, as the safety of the developing fetus and pregnant person …

Mucosal epithelia use osmotic gradients for fluid absorption and secretion. We hypothesized
that administration of hypotonic solutions would induce fluid uptake that could be …

The majority of newly discovered oral drugs are poorly water soluble, and co-administration
with lipids has proven effective in significantly enhancing bioavailability of some compounds …

Mucus is the first biological barrier encountered by particles and pathogenic bacteria at the
surface of secretory epithelia. The viscoelasticity of mucus is governed in part by low energy …

Purpose To assess the potential of polymeric nanoparticles (NPs) to affect the genital
distribution and local and systemic pharmacokinetics (PK) of the anti-HIV microbicide drug …