Modulating Vibrio cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles

HD Lu, AC Spiegel, A Hurley, LJ Perez, K Maisel… - Nano …, 2015 - ACS Publications
The rise of bacterial antibiotic resistance has created a demand for alternatives to traditional
antibiotics. Attractive possibilities include pro-and anti-quorum sensing therapies that …

Technological strategies to estimate and control diffusive passage times through the mucus barrier in mucosal drug delivery

JM Newby, I Seim, M Lysy, Y Ling, J Huckaby… - Advanced drug delivery …, 2018 - Elsevier
In mucosal drug delivery, two design goals are desirable: 1) insure drug passage through
the mucosal barrier to the epithelium prior to drug removal from the respective organ via …

Development of emulgel formulation for vaginal candidiasis: Pharmaceutical characterization, in vitro and in vivo evaluation

N Srivastava, DK Patel, VK Rai, A Pal… - Journal of drug delivery …, 2018 - Elsevier
The aim of the investigation was to develop nanoemulsion (NE) based emulgel of Mentha
essential oil (MEO: potent antifungal property) to ensure enriched and extended therapeutic …

Microrheology for biomaterial design

K Joyner, S Yang, GA Duncan - APL bioengineering, 2020 - pubs.aip.org
Microrheology analyzes the microscopic behavior of complex materials by measuring the
diffusion and transport of embedded particle probes. This experimental method can provide …

[HTML][HTML] LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus

HA Schroeder, J Newby, A Schaefer, B Subramani… - Mucosal …, 2020 - Elsevier
The gastrointestinal (GI) mucosa is coated with a continuously secreted mucus layer that
serves as the first line of defense against invading enteric bacteria. We have previously …

Mechanisms of carotenoid intestinal absorption and the regulation of dietary lipids: lipid transporter-mediated transintestinal epithelial pathways

Z Guo, Y Liu, Y Luo - Critical Reviews in Food Science and …, 2024 - Taylor & Francis
Dietary lipids are key ingredients during cooking, processing, and seasoning of carotenoid-
rich fruits and vegetables, playing vitals in affecting the absorption and utilization of …

A review of mixing and propulsion of chyme in the small intestine: fresh insights from new methods

RG Lentle, C De Loubens - Journal of Comparative Physiology B, 2015 - Springer
The small intestine is a convoluted flexible tube of inconstant form and capacity through
which chyme is propelled and mixed by varying patterns of contraction. These inconstancies …

Generating an In Vitro Gut Model with Physiologically Relevant Biophysical Mucus Properties

J McCright, A Sinha, K Maisel - Cellular and molecular bioengineering, 2022 - Springer
Introduction Gastrointestinal (GI) in vitro models have received lasting attention as an
effective tool to model drug and nutrient absorption, study GI diseases, and design new drug …

Nanomedicine for Maternal and Fetal Health

D Carter, M Better, S Abbasi, F Zulfiqar, R Shapiro… - Small, 2023 - Wiley Online Library
Conception, pregnancy, and childbirth are complex processes that affect both mother and
fetus. Thus, it is perhaps not surprising that in the United States alone, roughly 11% of …

Efficacy and safety concerns over the use of mucus modulating agents for drug delivery using nanoscale systems

PI Chater, MD Wilcox, JP Pearson - Advanced Drug Delivery Reviews, 2018 - Elsevier
Drug delivery to the mucus covered mucosae is fraught with difficulties and many different
approaches have been developed to permeate the mucus barrier. Generally by modifying …