Melanogenesis is a process to synthesize melanin, which is a primary responsible for the
pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and …

It is important that the medical profession play a significant role in critically evaluating the
use of diagnostic procedures and therapies as they are introduced and tested in the …

Background and Methods Aldosterone is important in the pathophysiology of heart failure. In
a double-blind study, we enrolled 1663 patients who had severe heart failure and a left …

Heart failure (HF) is a major and growing public health problem in the United States.
Approximately 5 million patients in this country have HF, and over 550 000 patients are …

Late-breaking clinical trials presented at the 2005, 2006, and 2007 annual scientific
meetings of the ACCF, AHA, and European Society of Cardiology, as well as selected other …

Tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining
the color of mammalian skin and hair. Various dermatological disorders, such as melasma …

Advances in cardiovascular research during the past two decades have resulted in an
improved understanding of the chain of events that lead to end-stage coronary artery …

Background Beta‐blockers and inhibitors of the renin‐angiotensin‐aldosterone system
improve survival and reduce morbidity in people with heart failure with reduced left …

BACKGROUND In patients with heart failure, activation of the renin-angiotensin system is
common and has been postulated to provide a stimulus for further left ventricular (LV) …

The American College of Cardiology (ACC)/American Heart Association (AHA) Task Force
on Practice Guidelines regularly reviews existing guidelines to determine when an update or …