Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

Recent applications of immunomodulatory biomaterials for disease immunotherapy

H Dai, Q Fan, C Wang - Exploration, 2022 - Wiley Online Library
Immunotherapy is used to regulate systemic hyperactivation or hypoactivation to treat
various diseases. Biomaterial‐based immunotherapy systems can improve therapeutic …

Immunosenescence, aging and successful aging

Y Wang, C Dong, Y Han, Z Gu, C Sun - Frontiers in immunology, 2022 - frontiersin.org
Aging induces a series of immune related changes, which is called immunosenescence,
playing important roles in many age-related diseases, especially neurodegenerative …

Immunosenescence and human vaccine immune responses

SN Crooke, IG Ovsyannikova, GA Poland… - Immunity & …, 2019 - Springer
The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
Abstract Purpose Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …

Comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatment strategies, and outcomes in adult and pediatric patients with COVID-19: A …

CR Jutzeler, L Bourguignon, CV Weis, B Tong… - Travel medicine and …, 2020 - Elsevier
Abstract Introduction Since December 2019, a novel coronavirus (SARS-CoV-2) has
triggered a world-wide pandemic with an enormous medical and societal-economic toll …

The impact of age difference on the efficacy and safety of COVID-19 vaccines: a systematic review and meta-analysis

J Wang, Y Tong, D Li, J Li, Y Li - Frontiers in immunology, 2021 - frontiersin.org
Objective This meta-analysis compared the efficacy and safety of five kinds of COVID-19
vaccines in different age groups (young adults and older adults), aiming to analyze the …

Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

A Grifoni, T Alonzi, G Alter, DMC Noonan… - Frontiers in …, 2023 - frontiersin.org
Knowledge of aging biology needs to be expanded due to the continuously growing number
of elderly people worldwide. Aging induces changes that affect all systems of the body. The …

The skin microbiome: current landscape and future opportunities

P Smythe, HN Wilkinson - International journal of molecular sciences, 2023 - mdpi.com
Our skin is the largest organ of the body, serving as an important barrier against the harsh
extrinsic environment. Alongside preventing desiccation, chemical damage and …

Enzyme therapy: current challenges and future perspectives

M de la Fuente, L Lombardero… - International Journal of …, 2021 - mdpi.com
In recent years, enzymes have risen as promising therapeutic tools for different pathologies,
from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint …