Dabrafenib is a BRAF inhibitor that has been demonstrated to be efficacious in the treatment
of melanoma and non-small-cell lung cancer patients with BRAF V600E mutations. The …

Angelica dahurica radix has a long history of traditional use in China and Korea for treating
headaches, cold-damp pain and skin diseases. Despite various pharmacological studies on …

Methotrexate is an important immunosuppressive and antineoplastic drug and is widely
used for treatment. However, hepatotoxicity is one of the major adverse effects of …

Liver disease is a common and serious threat to human health. The progression of liver
diseases is influenced by many physiologic processes, including oxidative stress …

Aromatic vinegar with abundant bioactive components can be used as a food additive to
assist the treatment of various diseases. However, its effect on non-alcoholic fatty liver …

Abrus cantoniensis Hance (AC) is popularly consumed as a kind of medicine homologous
food plant. This paper was to examine the hepatoprotective effects and mechanism of AC …

Polymerase δ-interacting protein 2 (Poldip2) has been reported to mediate acute lung injury
(ALI); however, the underlying mechanism is not fully explored. Male C57BL/6 mice and …

Acetaminophen (APAP) intake leads to excessive NAPQI deposition, stimulating
inflammatory and oxidative stress and causing fatal liver injury. However, the detailed …

Acetaminophen (APAP) overdose is a leading cause of acute hepatic failure and liver
transplantation, while the existing treatments are poorly effective. Therefore, it is necessary …

Aims: The exposition of drug-induced hepatotoxicity and nephron injury is highly uneven;
some range from asymptomatic but elevated liver and kidney parameters to meteoric liver …