Introduction Effusion cytology has a high sensitivity for the diagnosis of malignancy and
provides abundant material for molecular testing. Effusion draining is a minimally invasive …

We live in the “era” of minimally invasive procedures, molecular testing, and personalized
care. Effusions have a high sensitivity and will often yield diagnostic cytological material …

The International System for Reporting Serous Fluid Cytopathology (TIS) classifies serous
effusions into five categories: non-diagnostic (ND), negative for malignancy (NFM), atypia of …

Background Recently, plasma-derived exosomal DNA (exoDNA) has been successfully
used in clinical genetic testing. However, the clinical utility of pleural effusion-derived …

Cytology samples are increasingly used for comprehensive molecular testing. Although fine-
needle aspirates are adequate substrates for high-throughput sequencing, the suitability of …

Background Epidermal growth factor receptor (EGFR) mutation is the most frequent mutation
tested in lung cancer for targeted therapy in the era of personalized medicine. Knowledge …

Introduction The aim of this study was to examine whether a combined test using both cell
sediment and supernatant cytology cell‐free DNA (ccf DNA) is more useful in detecting …

Background: Pleural fluid can be used to assess targetable mutations in patients with lung
adenocarcinoma. The primary objective of this study was to assess the yield of pleural fluid …

Background Postprogression repeat biopsies are critical in caring for patients with lung
cancer with epidermal growth factor receptor (EGFR) mutations. However, hesitation about …

Lung cancer is the current leading cause of cancer-related deaths worldwide, and malignant
pleural effusion, an indicator of the advanced stage of this disease, portends a poor …