FGF receptors: cancer biology and therapeutics

M Katoh, H Nakagama - Medicinal research reviews, 2014 - Wiley Online Library
Fibroblast growth factors (FGFs) are involved in a variety of cellular processes, such as
stemness, proliferation, anti‐apoptosis, drug resistance, and angiogenesis. Here, FGF …

Recent advances and challenges of bispecific antibodies in solid tumors

Y Wu, M Yi, S Zhu, H Wang, K Wu - Experimental hematology & oncology, 2021 - Springer
Cancer immunotherapy has made remarkable progress in the past decade. Bispecific
antibodies (BsAbs) have acquired much attention as the next generation strategy of antibody …

Urea derivatives in modern drug discovery and medicinal chemistry

AK Ghosh, M Brindisi - Journal of medicinal chemistry, 2019 - ACS Publications
The urea functionality is inherent to numerous bioactive compounds, including a variety of
clinically approved therapies. Urea containing compounds are increasingly used in …

Selective estrogen receptor degraders (SERDs): a promising strategy for estrogen receptor positive endocrine-resistant breast cancer

Y Lu, W Liu - Journal of medicinal chemistry, 2020 - ACS Publications
Estrogen receptor (ER) plays important roles in gene transcription and the proliferation of ER
positive breast cancers. Selective modulation of ER has been a therapeutic target for this …

Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells

TL Fitzgerald, K Lertpiriyapong, L Cocco… - Advances in biological …, 2015 - Elsevier
Pancreatic cancer is currently the fourth most common cancer, is increasing in incidence
and soon will be the second leading cause of cancer death in the USA. This is a deadly …

Prognostic role of hormone receptors in endometrial cancer: a systematic review and meta-analysis

Y Zhang, D Zhao, C Gong, F Zhang, J He… - World journal of surgical …, 2015 - Springer
Background The aim of this study was to summarize the global predicting role of hormone
receptors for survival in endometrial cancer. Methods Eligible studies were identified and …

Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer

AM Espinosa, A Alfaro, E Roman-Basaure… - PloS one, 2013 - journals.plos.org
The effect of preventive human papillomavirus (HPV) vaccination on the reduction of the
cervical cancer (CC) burden will not be known for 30 years. Therefore, it's still necessary to …

[HTML][HTML] SERD-NHC-Au (I) complexes for dual targeting ER and TrxR to induce ICD in breast cancer

Y Lu, X Sheng, C Liu, Z Liang, X Wang, L Liu… - Pharmacological …, 2023 - Elsevier
The development of selective estrogen receptor degraders (SERDs) has brought new ideas
for the clinical treatment of ER-positive advanced breast cancer. The successful application …

Superbinder SH2 domains act as antagonists of cell signaling

T Kaneko, H Huang, X Cao, X Li, C Li, C Voss… - Science …, 2012 - science.org
Protein-ligand interactions mediated by modular domains, which often play important roles
in regulating cellular functions, are generally of moderate affinities. We examined the Src …

3D super-resolution imaging with blinking quantum dots

Y Wang, G Fruhwirth, E Cai, T Ng, PR Selvin - Nano letters, 2013 - ACS Publications
Quantum dots are promising candidates for single molecule imaging due to their exceptional
photophysical properties, including their intense brightness and resistance to …